ArticleEuropean journal of nuclear medicine and molecular imaging2024
Downward myocardial creep during stress PET imaging is inversely associated with mortality.
Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Trial
- Patient-centric performance and interpretation of positron emission tomography /computed tomography myocardial perfusion imaging: a clinical consensus statement of the European Association of Cardiovascular Imaging of the European Society of Cardiology.European heart journal. Imaging methods and practice · 2026Review
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2025Article
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Authors and funding
15 authors at 2 institutions in 3 countries.
Funding
Abstract
purposeThe myocardial creep is a phenomenon in which the heart moves from its original position during stress-dynamic PET myocardial perfusion imaging (MPI) that can confound myocardial blood flow measurements. Therefore, myocardial motion correction is important to obtain reliable myocardial flow quantification. However, the clinical importance of the magnitude of myocardial creep has not been explored. We aimed to explore the prognostic value of myocardial creep quantified by an automated motion correction algorithm beyond traditional PET-MPI imaging variables.
methodsConsecutive patients undergoing regadenoson rest-stress [
resultsA total of 4,276 patients (median age 71 years; 60% male) were analyzed, and 1,007 ACM events were documented during a 5-year median follow-up. Processing time for automatic motion correction was < 12 s per patient. Myocardial creep in the superior to inferior (downward) direction was greater than the other directions (median, 4.2 mm vs. 1.3-1.7 mm). Annual mortality rates adjusted for age and sex were reduced with a larger downward creep, with a 4.2-fold ratio between the first (0 mm motion) and 10th decile (11 mm motion) (mortality, 7.9% vs. 1.9%/year). Downward creep was associated with lower ACM after full adjustment for clinical and imaging parameters (adjusted hazard ratio, 0.93; 95%CI, 0.91-0.95; p < 0.001). Adding downward creep to the standard PET-MPI imaging model significantly improved ACM prediction (area under the receiver operating characteristics curve, 0.790 vs. 0.775; p < 0.001), but other directions did not (p > 0.5).
conclusionsDownward myocardial creep during regadenoson stress carries additional information for the prediction of ACM beyond conventional flow and perfusion PET-MPI. This novel imaging biomarker is quantified automatically and rapidly from stress dynamic PET-MPI.
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