Evidence map›Paper›PMID 38253901›Full record

ArticleMolecular biotechnology2024

MicroRNA-181b-5p Facilitates Thyroid Cancer Growth via Targeting Programmed Cell Death 4.

Xiang Geng, Yuan Li, YangYang Sun, Liang Cao, ZhenShun Song

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiang Geng *Department of Thyroid and Breast Surgery, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China.
Yuan Li *Department of Thyroid and Breast Surgery, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China.
YangYang SunDepartment of Pathology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China.
Liang CaoDepartment of General Surgery, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou City, 210029, Jiangsu Province, China.
ZhenShun SongDepartment of General Surgery, Shanghai Tenth People's Hospital, Clinical Medical College of Nanjing Medical University, 301 Yanchang Middle Road, Shanghai City, 200072, China. zs_songss@outlook.com.ORCID http://orcid.org/0000-0002-7344-9146
Changzhou No.2 People's Hospital · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the potential mechanism of microRNA (miR)-181b-5p promoting the progression of thyroid cancer (TC) by targeting programmed cell death 4 (PDCD4). Analysis of miR-181b-5p and PDCD4 expression in TC was performed. The impact of miR-181b-5p and PDCD4 on proliferation, migration, invasion, and apoptosis of TC cells was examined. The binding relationship between miR-181b-5p and PDCD4 was predicted and verified. miR-181b-5p was up-regulated in TC, while PDCD4 was down-regulated. Down-regulating miR-181b-5p or up-regulating PDCD4 inhibited the proliferation, migration, and invasion of TC cells, and promoted cell apoptosis. PDCD4 was the downstream target of miR-181b-5p, and down-regulation of PDCD4 counteracted the inhibitory effect of down-regulation of miR-181b-5p on the proliferation, migration, and invasion of TC cells and the promoting effect on apoptosis. miR-181b-5p inhibits the proliferation, migration, and invasion of TC cells and promotes cell apoptosis by targeting PDCD4.

Indexed as

ApoptosisApoptosis Regulatory ProteinsCell MovementCell ProliferationGene Expression Regulation, NeoplasticMicroRNAsRNA-Binding ProteinsThyroid NeoplasmsCell Line, TumorDown-RegulationFemaleHumansMaleMiddle AgedNeoplasm InvasivenessApoptosis Regulatory ProteinsMicroRNAsMIrn181 microRNA, humanPDCD4 protein, humanRNA-Binding ProteinsmicroRNA-181b-5pPDCD4Thyroid cancer

Identifiers

PMID38253901
OpenAlexW4391092807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.