Evidence map›Paper›PMID 38253706›Full record

ArticleScientific reports2024

Measurements of cadmium levels in relation to tobacco dependence and as a function of cytisine administration.

Karol Wróblewski, Julia Wojnicka, Piotr Tutka, Agnieszka Szmagara, Anna Błażewicz

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Karol WróblewskiLaboratory of Commercial and Non-Commercial Clinical Trials, University of Rzeszów, Kopisto 2a, 35-959, Rzeszow, Poland.ORCID 0000-0002-8918-7056
Julia WojnickaDepartment of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Chair of Biomedical Sciences, Medical University of Lublin, 1 Chodźki Street, 20-093, Lublin, Poland.ORCID 0000-0003-0769-5880
Piotr TutkaLaboratory for Innovative Research in Pharmacology, University of Rzeszów, Kopisto 2a, 35-959, Rzeszow, Poland.ORCID 0000-0001-5731-4295
Agnieszka SzmagaraFaculty of Medicine, Institute of Biological Sciences, Department of Chemistry, The John Paul II Catholic University of Lublin, Konstantynow 1J, 20-708, Lublin, Poland.ORCID 0000-0001-9483-058X
Anna BłażewiczDepartment of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Chair of Biomedical Sciences, Medical University of Lublin, 1 Chodźki Street, 20-093, Lublin, Poland. anna.blazewicz@umlub.pl.ORCID 0000-0001-9758-5831
Medical University of Lublin · PLJohn Paul II Catholic University of Lublin · PLUniversity of Rzeszów · PLUNSW Sydney · AU

Funding

Uniwersytet Medyczny w Lublinie DS 53
6 · The paper itself

Abstract

Cigarette smoking delivers a number of heavy metals, including cadmium (Cd), into the body. Bioaccumulation may result in an increase in pathological consequences over time. The assessment of changes in serum Cd concentrations during the treatment of cigarette dependence with cytisine was performed for the first time. Parameters assessing smoking habits, strength of addiction, and effectiveness of therapy were analyzed. Cd was determined before, during, and after the end of treatment. The serum Cd levels were significantly higher in the smokers than in the nonsmokers. Significant differences in Cd concentrations between sampling times in smokers were observed. Individuals who stopped smoking had significantly lower Cd concentrations compared to baseline. A significant positive correlation between the serum Cd before treatment and smoking urges was also obtained. Additionally, salivary Cd determinations were performed before treatment to evaluate the use of this method to assess cigarette addiction. Our findings indicate that Cd can be used as a biomarker of smoking addiction, and provide an alternative assessment of tobacco smoke exposure to other methods. The results provide new knowledge related to Cd concentrations in human body fluids and may play a role in monitoring and assessing the efficacy of cytisine for smoking cessation.

Indexed as

AlkaloidsCigarette SmokingQuinolizidine AlkaloidsTobacco Use DisorderAzocinesCadmiumHumansSmokingAlkaloidsAzocinesCadmiumcytisineQuinolizidine Alkaloids

Identifiers

PMID38253706
PMCPMC10803351
OpenAlexW4391104460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.