ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
Super-Resolution Ultrasound Reveals Cerebrovascular Impairment in a Mouse Model of Alzheimer's Disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.EBioMedicine · 2026Article
- Fast 3-D Ultrasound Localization Microscopy via Projection-Based Processing Framework.IEEE transactions on medical imaging · 2026Article
- Clinically translatable ultrasound localization microscopy reveals cerebrovascular remodelling and prognosis in patients with traumatic brain injury.Nature biomedical engineering · 2026Article
- CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026Article
- Multi-parametric longitudinal imaging of cerebral biomarkers in a rodent model of Alzheimer's disease.Photoacoustics · 2026Article
- Super-resolution ultrasound imaging indirectly reveals neurovascular uncoupling in substantia nigra of a Parkinson's disease model.NPJ Parkinson's disease · 2026Article
- Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging.Translational neurodegeneration · 2025Article
- High-Volume Acquisition Rate Nonlinear Imaging Enables Robust 3-D Ultrasound Localization Microscopy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery.Metabolites · 2025Review
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- Article
- Microvascular heterogeneity exploration in core and invasive zones of orthotopic rat glioblastoma via ultrasound localization microscopy.European radiology experimental · 2025Article
- 3D ultrasound localization microscopy of the nonhuman primate brain.EBioMedicine · 2025Article
- Non-invasive volumetric ultrasound localization microscopy detects vascular changes in mice with Alzheimer's disease.Theranostics · 2025Article
- Comparison of high-frequency ultrasound transducers for microvascular localization microscopy in the mouse brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Amyloid-β as a Key Player in Cerebrovascular Dysfunction in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Background Noise Removal in Non-Contrast- Enhanced Ultrasound Microvasculature Imaging Using Combined Collaborative, Morphological, and Vesselness Filtering.IEEE access : practical innovations, open solutions · 2024Article
- Localization Free Super-Resolution Microbubble Velocimetry Using a Long Short-Term Memory Neural Network.IEEE transactions on medical imaging · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Increasing evidence has suggested a link between cerebrovascular disease and the cognitive impairment associated with Alzheimer's disease. However, detailed descriptions of microvascular changes across brain regions and how they relate to other more traditional pathology have been lacking. Additionally, the efforts to elucidate the interplay between cerebral microvascular function and Alzheimer's disease progression are complicated by the necessity of probing deep-brain structures since early-stage Alzheimer's disease typically involves hippocampal pathology. The purpose of this study was to examine changes in microvascular dynamics in a mouse model of Alzheimer's disease using cohorts that were age-matched to wild-type controls. Data from both sexes were included in this study. Super-resolution ultrasound localization microscopy revealed microvascular functional and structural features throughout the whole brain depth to visualize and quantify. We found that functional decreases in hippocampal and entorhinal flow velocity preceded structural derangements in regional vascular density. Co-registered histological sectioning confirmed the regionalized perfusion deficits seen on ultrasound imaging, which were co-localized with amyloid beta plaque deposition. In addition to providing global vascular quantifications of deep brain structures with a high local resolution, this technology also permitted velocity-profile analysis of individual vessels and, in some cases, allowed for decoupling of arterial and venous flow contributions. These data suggest that microvascular pathology is an early and pervasive feature of Alzheimer's disease and may represent a novel therapeutic target for this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.