Evidence map›Paper›PMID 38253251›Full record

ArticleContemporary clinical trials2024

Study protocol and rationale for a pilot randomized clinical trial comparing processing of positive memories technique with supportive counseling for PTSD.

Ateka A Contractor, Heidemarie Blumenthal, David Rosenfield, M Tracie Shea, Daniel J Taylor, Andrea Fentem, Jakob L Vingren

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05523453 (Examination and Refinement of a Novel Treatment for Posttraumatic Stress Disorder), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05523453 nacompletednot on this map

Examination and Refinement of a Novel Treatment for Posttraumatic Stress Disorder: Processing of Positive Memories Technique (PPMT)

TypeinterventionalSponsorUniversity of North Texas, Denton, TXRan2023 to 2025Enrolled70ConditionsStress Disorders, Post-Traumatic, Affect, MemoryArmsProcessing of Positive Memories Technique (PPMT), Supportive Counseling (SC)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ateka A ContractorDepartment of Psychology, University of North Texas, Terrill Hall, Denton, TX, 76201, United States of America. Electronic address: ateka.contractor@unt.edu.
Heidemarie BlumenthalDepartment of Psychology, University of North Texas, Terrill Hall, Denton, TX, 76201, United States of America.
David RosenfieldDepartment of Psychology, Southern Methodist University, Expressway Tower, Dallas, TX, 75275, United States of America.
M Tracie SheaBox G-BH, Brown University, Providence, RI 02912, United States of America.
Daniel J TaylorDepartment of Psychology, University of Arizona, 1503 W University Blvd, Tuscon, AZ 85721, United States of America.
Andrea FentemDepartment of Psychology, University of North Texas, Terrill Hall, Denton, TX, 76201, United States of America.
Jakob L VingrenDepartment of Kinesiology, Health Promotion and Recreation, University of North Texas, Denton TX 76203, United States of America.

Funding

Examination and Refinement of a Novel Treatment for Posttraumatic Stress Disorder: Processing of Positive Memories Technique (PPMT)R15MH129773 · NIMH · UNIVERSITY OF NORTH TEXAS · PI CONTRACTOR, ATEKA · 2022 to 2022
$428k
NIMH NIH HHS R15 MH129773
6 · The paper itself

Abstract

backgroundResearch indicates that positive memories have a role in posttraumatic stress disorder's (PTSD) symptomatology and treatment. Following treatment development guidelines, a novel PTSD intervention - Processing of Positive Memories Technique (PPMT) - was developed and subsequently examined for its effects and feasibility in pilot studies. Extending this research, the proposed pilot randomized clinical trial with PPMT and Supportive Counseling (SC) arms will examine PPMT's effects on PTSD severity and biomarkers of stress systems' dysregulation (awakening salivary alpha amylase [sAA] and cortisol concentrations); examine mechanistic targets (affect) underlying PPMT's effects; and refine PPMT. We hypothesize that the PPMT arm will report greater decreases in PTSD severity and greater decreases in awakening sAA/cortisol ratio compared to the SC arm; and that improved affect (more positive affect and less negative affect) will mediate associations between intervention arm and changes in PTSD severity.

methodsWe will recruit 70 individuals aged 18-65 years with PTSD. They will be randomized to 5 weekly therapy sessions of PPMT or SC, and will be assessed at baseline, weekly during treatment, 1-week post-treatment, and 3-months post-treatment. Primary outcomes are past-week PTSD severity, past-week positive and negative affect levels, and feedback data on PPMT's feasibility, format, and content. The secondary outcome is the awakening sAA/cortisol ratio. Statistical analyses include mixed-effect models and within-subjects cross-lag longitudinal mediation analyses.

conclusionStudy results will advance knowledge of trauma interventions by examining effects and feasibility of a novel PTSD intervention, and by elucidating potential mechanisms underlying PPMT's effects. Clinical Trials #: NCT05523453.

Indexed as

Stress Disorders, Post-TraumaticCounselingHumansHydrocortisonePilot ProjectsRandomized Controlled Trials as TopicResearch DesignTreatment OutcomeHydrocortisonePosttraumatic stress disorderProcessing of positive memories techniqueRandomized clinical trialSupportive counselingTrauma

Identifiers

PMID38253251
PMCPMC11338315

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.