ArticleJournal of agricultural and food chemistry2024
Novel Synthesis of Phytosterol Ferulate Using Acidic Ionic Liquids as a Catalyst and Its Hypolipidemic Activity.
Article in Journal of agricultural and food chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 52 citations in OpenAlex.
- Stigmasterol-Acylglycerol Conjugates: Chemoenzymatic Synthesis as a Shorter Alternative to Chemical Routes and the Impact of Fatty Acid Chain Length on the Physicochemical Parameters of Liposomes.Molecules (Basel, Switzerland) · 2026Article
- Fabrication of collagen fiber films incorporated with different sourced hydrocolloids and the application in chilled meat preservation: a comparative study.Journal of the science of food and agriculture · 2026Article
- Phenolics Distribution in Rice and Their Macromolecular Interactions: A Matrix-Centric Perspective.Foods (Basel, Switzerland) · 2026Review
- Role of Mushroom Polysaccharides in Modulation of GI Homeostasis and Protection of GI Barrier.Journal of agricultural and food chemistry · 2025Review
- Carotenoid and Phenolic Compositions and Antioxidant Activity of 23 Cultivars of Corn Grain and Corn Husk Extract.Foods (Basel, Switzerland) · 2024Article
- Enzymatic Synthesis of a Novel Antioxidant Octacosanol Lipoate and Its Antioxidant Potency in Sunflower Oil.Journal of agricultural and food chemistry · 2024Article
- Exploring Phytochemical Mechanisms in the Prevention of Cholesterol Dysregulation: A Review.Journal of agricultural and food chemistry · 2024Review
- Dietary bamboo charcoal powder ameliorates high-fat diet-induced hyperlipidemia by enhancing fecal lipid excretions in Sprague-Dawley rats.Frontiers in nutrition · 2024Article
- Virtual screening and evaluation of bioactive peptides fromFrontiers in nutrition · 2024Article
- Walnut oil prevents hyperlipidemia induced by high-fat diet and regulates intestinal flora and liver metabolism.Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytosterol ferulate (PF) is quantitively low in rice, corn, wheat, oats, barley, and millet, but it is potentially effective in reducing plasma lipids. In this study, PF was synthesized for the first time using acidic ionic liquids as a catalyst. The product was purified, characterized using Fourier transform infrared, mass spectroscopy, and nuclear magnetic resonance, and ultimately confirmed as the desired PF compound. The conversion of phytosterol surpassed an impressive 99% within just 2 h, with a selectivity for PF exceeding 83%. Plasma lipid-lowering activity of PF was further investigated by using C57BL/6J mice fed a high-fat diet as a model. Supplementation of 0.5% PF into diet resulted in significant reductions in plasma total cholesterol, triacylglycerols, and nonhigh-density lipoprotein cholesterol by 13.7, 16.9, and 46.3%, respectively. This was accompanied by 55.8 and 36.3% reductions in hepatic cholesterol and total lipids, respectively, and a 22.9% increase in fecal cholesterol excretion. Interestingly, PF demonstrated a higher lipid-lowering activity than that of its substrates, a physical mixture of phytosterols and ferulic acid. In conclusion, an efficient synthesis of PF was achieved for the first time, and PF had the great potential to be developed as a lipid-lowering dietary supplement.
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