Evidence map›Paper›PMID 38252624›Full record

ArticleJournal of medicinal chemistry2024

Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.

Faisal Aziz, Kanamata Reddy, Virneliz Fernandez Vega, Raja Dey, Katherine A Hicks, Sumitha Rao, Luis Ortiz Jordan, Emery Smith, Justin Shumate, Louis Scampavia and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Focusing on CD8Journal of experimental & clinical cancer research : CR · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Faisal AzizThe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.
Kanamata ReddyThe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.
Virneliz Fernandez VegaDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Raja DeyThe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.
Katherine A HicksDepartment of Chemistry, State University of New York at Cortland, Cortland, New York 13045, United States.ORCID 0000-0002-1474-1067
Sumitha RaoDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Luis Ortiz JordanDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Emery SmithDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Justin ShumateDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Louis ScampaviaDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Nicholas CarpinoDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York 11790, United States.
Timothy P SpicerDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.
Jarrod B FrenchThe Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.ORCID 0000-0002-6762-1309
Scripps Research Institute · USUniversity of Minnesota · USStony Brook University · USSUNY Cortland · US

Funding

Optimizing the immune response by targeting the Sts enzymesR01AI141592 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI CARPINO, NICHOLAS A, FRENCH, JARROD B · 2019 to 2022
$2.4M
Mechanisms that govern assembly and function of higher order protein structures of purine metabolic enzymesR35GM124898 · NIGMS · UNIVERSITY OF MINNESOTA · PI FRENCH, JARROD B · 2017 to 2021
$2.2M
Integrated Acoustic Transfer System for HTS Library ManagementS10OD025279 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2018 to 2018
$624k
Tandem Multi-modal Plate Readers for a High Throughput Screening platformS10OD030330 · OD · UNIVERSITY OF FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2021 to 2021
$600k
HTS Drug  Discovery DispensersS10OD026857 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2019 to 2019
$452k
Function of the Sts protein phosphodiesterase domainR21AI156238 · NIAID · UNIVERSITY OF MINNESOTA · PI FRENCH, JARROD B · 2021 to 2022
$445k
NIAID NIH HHS R01 AI141592NIAID NIH HHS R21 AI156238NIGMS NIH HHS R35 GM124898NIH HHS S10 OD025279NIH HHS S10 OD026857NIH HHS S10 OD030330
6 · The paper itself

Abstract

The suppressor of T cell receptor signaling (Sts) proteins are negative regulators of immune signaling. Genetic inactivation of these proteins leads to significant resistance to infection. From a 590,000 compound high-throughput screen, we identified the 2-(

Indexed as

HistidineQuinolonesAlanineEnzyme InhibitorsPhosphoric Monoester HydrolasesReceptors, Antigen, T-CellAlanineEnzyme InhibitorsHistidinePhosphoric Monoester HydrolasesQuinolonesrebamipideReceptors, Antigen, T-Cell

Identifiers

PMID38252624
PMCPMC11426313
OpenAlexW4391095610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.