Evidence map›Paper›PMID 38252319›Full record

ArticleJournal of cancer research and clinical oncology2024

The effect of resistin on the redox state of breast cancer cells.

Elitsa Pavlova, Radoslav Stojchevski, Dimiter Avtanski

Open access · goldAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Elitsa PavlovaFaculty of Physics, Sofia University "St. Kliment Ohridski", 5 James Boucher Blvd., 1164, Sofia, Bulgaria. elli_pavlova@abv.bg.
Radoslav StojchevskiFriedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, New York, NY, 10022, USA.
Dimiter AvtanskiFriedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, New York, NY, 10022, USA.
Northwell Health · USSofia University "St. Kliment Ohridski" · BG

Funding

Bulgarian-American Commission for Educational Exchange FULBRIGHT, Bulgaria 21-21-04
6 · The paper itself

Abstract

purposeResistin is an inflammatory cytokine secreted mostly by adipocytes and immune cells that plays a role in the development of insulin resistance, diabetes, and cancer. We hypothesized that resistin's inflammatory activity influences the free radical and oxidative stress pathways.

methodsWe used human breast carcinogenic (MCF-7 and MDA-MB-231) and non-carcinogenic (MCF-10A) cells in this investigation and correlated the absorbed resistin concentration with the change in oxidative stress (TBARS, carbonated proteins) and antioxidant activity (Antioxidant Capacity, SuperOxideDismutase, CATalase, Glutathione Peroxidase).

resultsResistin was substantially more effective as a prooxidant at lower (12.5 ng/ml) concentrations, than at higher concentrations (25.0 ng/ml). Vitamin C did not appear to be an effective oxidative stress protector at antioxidant concentrations of 5.10

conclusionTaken together, the findings support resistin's role as a non-oxidative stress marker and a metabolic signaling molecule.

Indexed as

AntioxidantsBreast NeoplasmsFemaleHumansOxidation-ReductionOxidative StressResistinAntioxidantsResistinAntioxidant activityBreast cancerLeptinOxidative stressResistinVitamin C

Identifiers

PMID38252319
PMCPMC10803585
OpenAlexW4391103818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.