SynthesisIntensive care medicine2024
Hypotension during intensive care stay and mortality and morbidity: a systematic review and meta-analysis.
Synthesis in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- Blood Pressure Targets for Adults with Vasodilatory Shock - An Individual Patient Data Meta-Analysis.NEJM evidence · 2025Pooled it
- Association of hypotension burden calculated from intermittently documented blood pressures and outcome after pediatric cardiac arrest.Resuscitation · 2026Article
- Alarm configuration and adherence to prescribed mean arterial pressure targets in the intensive care unit: A multicentre pre-post evaluation.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Article
- Association between prolonged Emergency Department stay and Intensive Care Unit mortality among patients at a tertiary hospital in Ethiopia.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2026Article
- Targeting and monitoring mean arterial pressure in critical illness: A mixed-methods service evaluation.Journal of the Intensive Care Society · 2026Article
- Early postoperative factors associated with in-hospital mortality after emergency noncardiac surgery: A Japanese nationwide registry-based intensive care unit cohort study.Scientific reports · 2026Observational
- Article
- Subphenotyping hypotension in early sepsis: A physiology-guided therapeutic approach.Annals of intensive care · 2026Article
- Nutritional Risk and 30-Day In-Hospital Mortality in Adults With Sepsis and Septic Shock: A Retrospective Cohort Study.Journal of nursing management · 2026Article
- Blood pressure response index and acute kidney injury progression in heart failure patients: a retrospective cohort study from MIMIC-IV.BMC nephrology · 2025Article
- Applied physiology at the bedside: using invasive blood pressure as a true monitoring tool.Annals of intensive care · 2025Review
- Knockoff-ML: a knockoff machine learning framework for controlled variable selection and risk stratification in electronic health record data.NPJ digital medicine · 2025Article
- Prediction of financial deficits of postoperative patients in the intensive care unit using machine learning.JA clinical reports · 2025Article
- Implementing prehospital invasive arterial blood pressure monitoring in critically ill patients-a prospective observational first year analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Hemodynamic Effects of Guideline-Based Sedation in Mechanically Ventilated Adults: A Multicenter Observational Analysis.Critical care explorations · 2025Observational
- Early Prediction of In-Hospital Mortality in Patients with Acute Infections: Development of the Acute Severity Infection Score (ASIs).Infectious diseases and therapy · 2025Article
- Predictors of intradialytic hypotension in critically ill patients undergoing kidney replacement therapy: a systematic review.Intensive care medicine experimental · 2024Review
- Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients.Journal of personalized medicine · 2024Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to provide a summary of the existing literature on the association between hypotension during intensive care unit (ICU) stay and mortality and morbidity, and to assess whether there is an exposure-severity relationship between hypotension exposure and patient outcomes.
methodsCENTRAL, Embase, and PubMed were searched up to October 2022 for articles that reported an association between hypotension during ICU stay and at least one of the 11 predefined outcomes. Two independent reviewers extracted the data and assessed the risk of bias. Results were gathered in a summary table and studies designed to investigate the hypotension-outcome relationship were included in the meta-analyses.
resultsA total of 122 studies (176,329 patients) were included, with the number of studies varying per outcome between 0 and 82. The majority of articles reported associations in favor of 'no hypotension' for the outcomes mortality and acute kidney injury (AKI), and the strength of the association was related to the severity of hypotension in the majority of studies. Using meta-analysis, a significant association was found between hypotension and mortality (odds ratio: 1.45; 95% confidence interval (CI) 1.12-1.88; based on 13 studies and 34,829 patients), but not for AKI.
conclusionExposure to hypotension during ICU stay was associated with increased mortality and AKI in the majority of included studies, and associations for both outcomes increased with increasing hypotension severity. The meta-analysis reinforced the descriptive findings regarding mortality but did not yield similar support for AKI.
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