Evidence map›Paper›PMID 38252220›Full record

SynthesisInflammopharmacology2024

The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis.

Hadis Razmaray, Ehsan Nasiri, Pouya Vakilipour, Soroush Morsali, Afshin Moradi, Asal Ebrahimian, Sahel Rashidi, Reza Mosaddeghi-Heris, Saeed Sadigh-Eteghad, Amirreza Naseri

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Melatonin supplementation: new insights into health and disease.Sleep & breathing = Schlaf & Atmung · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hadis RazmarayStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran.ORCID http://orcid.org/0009-0003-5904-1691
Ehsan NasiriStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran.ORCID http://orcid.org/0000-0002-9679-5623
Pouya VakilipourStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran.ORCID http://orcid.org/0000-0003-2244-043X
Soroush MorsaliStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran.ORCID http://orcid.org/0000-0003-3681-9408
Afshin MoradiStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran.ORCID http://orcid.org/0000-0003-2525-3664
Asal EbrahimianStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran.ORCID http://orcid.org/0009-0002-1613-9747
Sahel RashidiFaculty of Medicine, Dokuz Eylül University, Izmir, Türkiye.ORCID http://orcid.org/0009-0008-0142-8929
Reza Mosaddeghi-HerisNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/614756, East Azerbaijan, Iran.ORCID http://orcid.org/0000-0002-3353-1102
Saeed Sadigh-EteghadNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/614756, East Azerbaijan, Iran. Saeed.sadigetegad@gmail.com.ORCID http://orcid.org/0000-0003-2872-1072
Amirreza NaseriStudent Research Committee, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, 5166/15731, East Azerbaijan, Iran. Amirx2eza@gmail.com.ORCID http://orcid.org/0000-0001-9723-0109
Tabriz University of Medical Sciences · IRDokuz Eylül University · TR

Funding

Student Research Committee, Tabriz University of Medical Sciences grant number: 71005
6 · The paper itself

Abstract

backgroundThrough the antioxidant and anti-inflammation pathways, melatonin is proposed as a safe and effective intervention in neurological diseases. This study aims to evaluate the effects of melatonin supplementation on the neurobehavioral and clinical outcomes in animal models of multiple sclerosis (MS).

methodsThis study was conducted following the PRISMA statement. Animal studies that reported the effects of melatonin in preclinical MS models, including the experimental autoimmune encephalomyelitis (EAE) and cuprizone model for demyelination are included in this study. A systematic search in PubMed, Web of Science, Embase, and Scopus up was conducted in April 2023. The collaborative Approach to Meta-Analysis and Review of Animal Experimental Studies (CAMARADES) critical appraisal tool was used for the quality assessment of the studies and the quantitative synthetizes were conducted using the comprehensive meta-analysis software.

resultsOut of 542 studies, finally 21 studies, including 14 studies in the EAE model and 7 studies of the toxic demyelination method with cuprizone were included. The route of administration was intraperitoneal in 18 studies, oral in 2 studies, and subcutaneous in 1 study. The quantitative synthesis of the EAE clinical severity scale was associated with significant differences (standardized mean difference [SDM]: - 2.52; - 3.61 to - 1.42; p value < 0.01). In subgroup analyses, the difference was statistically significant in the mouse subgroup (SMD: - 2.60; - 3.74 to - 1.46; p value < 0.01). DISCUSSION: This study encountered that melatonin may be associated with improved behavioral and cognitive outcomes of preclinical models of MS with acceptable safety profiles.

fundingThe research was supported by the Student Research Committee, Tabriz University of Medical Sciences (grant number: 71005).

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMelatoninMultiple SclerosisAnimalsAntioxidantsBehavior, AnimalCuprizoneDietary SupplementsDisease Models, AnimalMiceRodentiaSeverity of Illness IndexAntioxidantsCuprizoneMelatoninMelatoninMeta-analysisMultiple sclerosisRodentSystematic review

Identifiers

PMID38252220
OpenAlexW4391103489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.