Evidence map›Paper›PMID 38252134›Full record

ArticleLung2024

Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study.

Duong Duc Pham, Ji-Hyang Lee, Hyouk-Soo Kwon, Woo-Jung Song, You Sook Cho, Hyunkyoung Kim, Jae-Woo Kwon, So-Young Park, Sujeong Kim, Gyu Young Hur and 19 more

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Early real-life outcomes of dupilumab and mepolizumab in patients with uncontrolled primary diffuse type 2 chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 19 institutions in 2 countries.

Duong Duc PhamDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Ji-Hyang LeeDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Hyouk-Soo KwonDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Woo-Jung SongDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
You Sook ChoDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Hyunkyoung KimDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
Jae-Woo KwonDepartment of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea.
So-Young ParkDivision of Pulmonary, Allergy and Critical Care Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
Sujeong KimDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Gyu Young HurDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Byung Keun KimDepartment of Internal Medicine, Korea University Medical Center Anam Hospital, Seoul, Korea.
Young-Hee NamDepartment of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Min-Suk YangDepartment of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.
Mi-Yeong KimDepartment of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Sae-Hoon KimDepartment of Internal Medicine, Division of Allergy and Clinical Immunology, Seoul National University Bundang Hospital, Seongnam, Korea.
Byung-Jae LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Taehoon LeeDepartment of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
So-Young ParkDepartment of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
Min-Hye KimDepartment of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
Young-Joo ChoDepartment of Allergy and Clinical Immunology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
ChanSun ParkDepartment of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea.
Jae-Woo JungDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Han Ki ParkDepartment of Allergy and Clinical Immunology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
Joo-Hee KimDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Ji-Yong MoonDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
Pankaj BhavsarNational Heart and Lung Institute, Imperial College London, London, UK.
Ian AdcockNational Heart and Lung Institute, Imperial College London, London, UK.
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, UK.
Tae-Bum KimDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea. tbkim@amc.seoul.kr.
University of Ulsan · KRAsan Medical Center · KRImperial College London · GBChung-Ang University · KREwha Womans University · KRSeoul National University Bundang Hospital · KRDong-A University · KREulji University · KRHallym University Sacred Heart Hospital · KRHanyang University · KRInje University Busan Paik Hospital · KRInje University Haeundae Paik Hospital · KRKangwon National University · KRKorea University · KRKorea University Medical Center · KRKyungpook National University Hospital · KRSeoul Metropolitan Government · KRSungkyunkwan University · KRUlsan College · KR

Funding

Medical Research Council MR/T010371/1
6 · The paper itself

Abstract

backgroundThe determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asthma (SEA) on biological treatment (BioT) remain elusive.

objectiveWe sought to identify the predictors of early and late lung function improvement in patients with SEA after BioT.

methods140 adult patients with SEA who received mepolizumab, dupilumab, or reslizumab were followed up for 6 months to evaluate improvement in forced expiratory volume in one second (FEV

resultsMore than a third of patients with SEA using BioT showed early and sustained improvements in FEV

conclusionFactors predicting the efficacy of biological agents that improve lung function in SEA vary according to the stage of response.

Indexed as

Anti-Asthmatic AgentsAsthmaBiological ProductsPulmonary EosinophiliaAdultEosinophilsHumansLungAnti-Asthmatic AgentsBiological ProductsBiologicsEarly and late responseLung functionSevere eosinophilic asthma

Identifiers

PMID38252134
OpenAlexW4391105822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.