Evidence map›Paper›PMID 38251930›Full record

ArticleNano letters2024

Ultrasensitive and Rapid Detection of Procalcitonin via Waveguide-Enhanced Nanogold-Linked Immunosorbent Assay for Early Sepsis Diagnosis.

Devesh Barshilia, Jhen-Jie Huang, Akhil Chandrakanth Komaram, Yi-Che Chen, Chun-Da Chen, Min-Yu Syu, Wen-Cheng Chao, Lai-Kwan Chau, Guo-En Chang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Devesh BarshiliaDepartment of Mechanical Engineering, National Chung Cheng University, Chiayi 621301, Taiwan.ORCID 0009-0000-1719-9317
Jhen-Jie HuangDepartment of Chemistry and Biochemistry, National Chung Cheng University, Chiayi 621301, Taiwan.
Akhil Chandrakanth KomaramDepartment of Chemistry and Biochemistry, National Chung Cheng University, Chiayi 621301, Taiwan.
Yi-Che ChenDepartment of Chemistry and Biochemistry, National Chung Cheng University, Chiayi 621301, Taiwan.
Chun-Da ChenDepartment of Laboratory Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin 640, Taiwan.
Min-Yu SyuDepartment of Laboratory Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin 640, Taiwan.
Wen-Cheng ChaoDepartment of Critical Care Medicine, Taichung Veterans General Hospital, Taichung 402202, Taiwan.
Lai-Kwan ChauDepartment of Chemistry and Biochemistry, National Chung Cheng University, Chiayi 621301, Taiwan.ORCID 0000-0002-1659-6465
Guo-En ChangDepartment of Mechanical Engineering, National Chung Cheng University, Chiayi 621301, Taiwan.ORCID 0000-0002-3739-5451
National Chung Cheng University · TWNational Taiwan University Hospital · TWTaichung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis, a life-threatening inflammatory response, demands economical, accurate, and rapid detection of biomarkers during the critical "golden hour" to reduce the patient mortality rate. Here, we demonstrate a cost-effective waveguide-enhanced nanogold-linked immunosorbent assay (WENLISA) based on nanoplasmonic waveguide biosensors for the rapid and sensitive detection of procalcitonin (PCT), a sepsis-related inflammatory biomarker. To enhance the limit of detection (LOD), we employed sandwich assays using immobilized capture antibodies and detection antibodies conjugated to gold nanoparticles to bind the target analyte, leading to a significant evanescent wave redistribution and strong nanoplasmonic absorption near the waveguide surface. Experimentally, we detected PCT for a wide linear response range of 0.1 pg/mL to 1 ng/mL with a record-low LOD of 48.7 fg/mL (3.74 fM) in 8 min. Furthermore, WENLISA has successfully identified PCT levels in the blood plasma of patients with sepsis and healthy individuals, offering a promising technology for early sepsis diagnosis.

Indexed as

Biosensing TechniquesMetal NanoparticlesSepsisAntibodies, ImmobilizedBiomarkersGoldHumansImmunosorbentsProcalcitoninAntibodies, ImmobilizedBiomarkersGoldImmunosorbentsProcalcitoninOptical biosensorParticle plasmon resonancePlanar waveguidePoint of careProcalcitoninSepsis

Identifiers

PMID38251930
PMCPMC10906069
OpenAlexW4391102417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.