ArticleScandinavian journal of primary health care2024
The durability of previous examinations for cancer: Danish nationwide cohort study.
Article in Scandinavian journal of primary health care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Changes in diagnostic evaluation of patients with lung cancer symptoms.NPJ primary care respiratory medicine · 2025Article
- How do health literacy and chronic disease influence the diagnostic evaluation of patients with lung cancer symptoms?Acta oncologica (Stockholm, Sweden) · 2025Article
- Smoking status, symptom significance and healthcare seeking with lung cancer symptoms in the Danish general population.NPJ primary care respiratory medicine · 2025Article
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Authors and funding
4 authors.
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Abstract
objectivePatients previously examined for cancer with a negative result may present in general practice with ongoing or new symptoms or signs suggestive of cancer. This paper explores the potential existence of a relatively safe period for cancer occurrence after receiving negative examination results for specific types of cancer, including lung (CT thorax), upper gastrointestinal (gastroscopy), colorectal (colonoscopy), bladder (cystoscopy), and breast (clinical mammography).
designRegister-based time-to-event analyses.
settingDenmark. SUBJECTS: All 3.3 million citizens aged 30-85 years who on January first, 2017, had not previously been diagnosed with the specific type of cancer were categorized based on the time since their most recent examination.
main outcome measuresUsing 1-year follow-up, we calculated the age- and sex-adjusted hazard ratios of being diagnosed with the related cancer, with non-examined individuals as reference. Negative examination results were defined as the absence of a cancer diagnosis within 6 months following the examination.
resultsPrevious negative examination results were common, also among those diagnosed with cancer during follow-up. For 10 years after a negative colonoscopy the risk of diagnosing a colorectal cancer was nearly halved. However, already 1 year after a clinical mammography and 2 years after a CT thorax the risk of diagnosing the related cancers was significantly higher among those with a previous negative result compared to non-examined individuals.
conclusionThis study did not identify a post-examination period in which the cancer risk, compared to non-examined individuals, was sufficiently low to confidently rule out any of the investigated cancers.
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