Evidence map›Paper›PMID 38251257›Full record

ArticleToxins2024

TDP-43 and Alzheimer's Disease Pathology in the Brain of a Harbor Porpoise Exposed to the Cyanobacterial Toxin BMAA.

Susanna P Garamszegi, Daniel J Brzostowicki, Thomas M Coyne, Regina T Vontell, David A Davis

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Alzheimer's Disease Neuropathological Change in Aged Non-Primate Mammals.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Susanna P GaramszegiDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0009-0004-6248-9371
Daniel J BrzostowickiDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Thomas M CoyneDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
Regina T VontellDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-2664-8265
David A DavisDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-9323-6180
University of Miami · USUniversity of Florida · US

Funding

Herbert W. Hoover Foundation GR012556 DAVIS
6 · The paper itself

Abstract

Cetaceans are well-regarded as sentinels for toxin exposure. Emerging studies suggest that cetaceans can also develop neuropathological changes associated with neurodegenerative disease. The occurrence of neuropathology makes cetaceans an ideal species for examining the impact of marine toxins on the brain across the lifespan. Here, we describe TAR DNA-binding protein 43 (TDP-43) proteinopathy and Alzheimer's disease (AD) neuropathological changes in a beached harbor porpoise (

Indexed as

Alzheimer DiseaseNeurodegenerative DiseasesPhocoenaAnimalsBrainDNA-Binding ProteinsDNA-Binding Proteinsblue green algae bloomcetacean strandingGuam ALS/PDCmarine food webmarine neurotoxintoothed whales

Identifiers

PMID38251257
PMCPMC10821503
OpenAlexW4390793263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.