ReviewToxics2024
2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers.
Review in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Occupational exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) and associated oxidative and genomic biomarkers among soybean farmers: a cross-sectional study.Journal, genetic engineering & biotechnology · 2026Article
- Comparative study of the degradation of the 2,4-dichlorophenoxyacetic acid herbicide using zinc oxide and zinc oxide/graphene oxide photocatalysts: efficiency, stability, toxicity, kinetics and mechanism insights.Environmental science and pollution research international · 2026Article
- Comparative Study of Hydrolysis-Based Methods Coupled with QuEChERS Extraction Followed by GC-MS/MS and LC-MS/MS for the Determination of Complex Pesticide Residues in Melons and Dry Beans.Foods (Basel, Switzerland) · 2026Article
- Article
- Impact of Ayurvedic purification (Shodhana) onFrontiers in medicine · 2026Article
- Urinary pesticide profiles and liver disease risk in Thailand: a machine-learning risk-prediction model.medRxiv : the preprint server for health sciences · 2025Article
- Modulating effect of glutathione (GSH) on 2,4-dichlorophenoxyacetic acid (2,4-D) toxicity.Scientific reports · 2025Article
- Synthesis of magnetic FeRSC advances · 2024Article
- Correlation between Early Life Exposure to Regulatory Relevant Doses of Herbicide Mixtures Based on Glyphosate and Development of Liver Dysfunction.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide worldwide and is frequently found in water samples. This knowledge has prompted studies on its effects on non-target organisms, revealing significant alterations to liver structure and function. In this review, we evaluated the literature on the hepatotoxicity of 2,4-D, focusing on morphological damages, toxicity biomarkers and affected liver functions. Searches were conducted on PubMed, Web of Science and Scopus and 83 articles were selected after curation. Among these studies, 72% used in vivo models and 30% used in vitro models. Additionally, 48% used the active ingredient, and 35% used commercial formulations in exposure experiments. The most affected biomarkers were related to a decrease in antioxidant capacity through alterations in the activities of catalase, superoxide dismutase and the levels of malondialdehyde. Changes in energy metabolism, lipids, liver function, and xenobiotic metabolism were also identified. Furthermore, studies about the effects of 2,4-D in mixtures with other pesticides were found, as well as hepatoprotection trials. The reviewed data indicate the essential role of reduction in antioxidant capacity and oxidative stress in 2,4-D-induced hepatotoxicity. However, the mechanism of action of the herbicide is still not fully understood and further research in this area is necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.