Evidence map›Paper›PMID 38250960›Full record

ArticleTomography (Ann Arbor, Mich.)2024

Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla.

Elles P Elschot, Walter H Backes, Marieke van den Kerkhof, Alida A Postma, Abraham A Kroon, Jacobus F A Jansen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Elles P ElschotDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0003-3284-6265
Walter H BackesDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Marieke van den KerkhofDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Alida A PostmaDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Abraham A KroonCARIM School for Cardiovascular Diseases, Maastricht University, Minderbroedersberg 4-6, P.O. Box 616, 6200 MD Maastricht, The Netherlands.ORCID 0000-0001-7750-8249
Jacobus F A JansenDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.ORCID 0000-0002-5271-8060
University Medical Center · US

Funding

ZonMw 446002509
6 · The paper itself

Abstract

Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated. Higher CBV and CBF values were found in CGM compared to WM, whereby the CGM-to-WM ratios depended on the amount of largest vessels excluded from the analysis. CBF was negatively associated with age in the CGM, while no significant association was found with CBV. Both CBV and CBF were higher in women compared to men in both CGM and WM. The current study verifies the possibility of quantifying cerebral microvascular perfusion with SE-DSC MRI at 7 T.

Indexed as

Cerebral Blood VolumeWhite MatterAdultAgedFemaleHumansMagnetic Resonance ImagingMalePerfusion7 Teslacerebral blood flowdynamic susceptibility contrastmicrovascular perfusionspin echoultra-high field

Identifiers

PMID38250960
PMCPMC10819808
OpenAlexW4391025954

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.