Evidence map›Paper›PMID 38250904›Full record

ArticleVaccines2024

Differences in Responses of Immunosuppressed Kidney Transplant Patients to Moderna mRNA-1273 versus Pfizer-BioNTech.

Dulat Bekbolsynov, Andrew Waack, Camryn Buskey, Shalmali Bhadkamkar, Keegan Rengel, Winnifer Petersen, Mary Lee Brown, Tanaya Sparkle, Dinkar Kaw, Fayeq Jeelani Syed and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Dulat BekbolsynovDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-3626-4310
Andrew WaackDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Camryn BuskeyDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0001-8364-9160
Shalmali BhadkamkarDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Keegan RengelDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Winnifer PetersenDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Mary Lee BrownDepartment of Urology, University of Toledo, Toledo, OH 43614, USA.
Tanaya SparkleDepartment of Anesthesiology, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0001-8381-9238
Dinkar KawDepartment of Internal Medicine, University of Toledo, Toledo, OH 43614, USA.
Fayeq Jeelani SyedDepartment of Electrical Engineering and Computer Science, University of Toledo, Toledo, OH 43614, USA.
Saurabh ChattopadhyayDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0002-2930-1523
Ritu ChakravartiDepartment of Physiology, University of Toledo, Toledo, OH 43614, USA.ORCID 0000-0003-4680-8374
Sadik KhuderDepartment of Internal Medicine, University of Toledo, Toledo, OH 43614, USA.
Beata MierzejewskaDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Michael ReesDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
Stanislaw StepkowskiDepartment of Medical Microbiology and Immunology, University of Toledo, Toledo, OH 43614, USA.
University of Toledo Medical Center · USUniversity of Toledo · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosuppressed kidney transplant (KT) recipients produce a weaker response to COVID-19 vaccination than immunocompetent individuals. We tested antiviral IgG response in 99 KT recipients and 66 healthy volunteers who were vaccinated with mRNA-1273 Moderna or BNT162b2 Pfizer-BioNTech vaccines. A subgroup of participants had their peripheral blood leukocytes (PBLs) evaluated for the frequency of T helper 1 (Th1) cells producing IL-2, IFN-γ and/or TNF-α, and IL-10-producing T-regulatory 1 (Tr) cells. Among KT recipients, 45.8% had anti-SARS-CoV-2 IgG compared to 74.1% of healthy volunteers (

Indexed as

immunocompromisedkidney transplantationmRNA vaccineSARS-CoV-2seropositivity

Identifiers

PMID38250904
PMCPMC10819652
OpenAlexW4390954906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.