Evidence map›Paper›PMID 38250843›Full record

ReviewVaccines2023

Nanoparticles and Antiviral Vaccines.

Sen Liu, Meilin Hu, Xiaoqing Liu, Xingyu Liu, Tao Chen, Yiqiang Zhu, Taizhen Liang, Shiqi Xiao, Peiwen Li, Xiancai Ma

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sen LiuGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Meilin HuGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Xiaoqing LiuGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Xingyu LiuGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Tao ChenGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Yiqiang ZhuGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Taizhen LiangGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Shiqi XiaoGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Peiwen LiGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.
Xiancai MaGuangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510005, China.ORCID 0000-0002-4934-4221
State Key Laboratory of Respiratory Disease · CNSun Yat-sen University · CNSouth China University of Technology · CN

Funding

National Natural Science Foundation of China 82102385R&D Program of Guangzhou National Laboratory SRPG22-006
6 · The paper itself

Abstract

Viruses have threatened human lives for decades, causing both chronic and acute infections accompanied by mild to severe symptoms. During the long journey of confrontation, humans have developed intricate immune systems to combat viral infections. In parallel, vaccines are invented and administrated to induce strong protective immunity while generating few adverse effects. With advancements in biochemistry and biophysics, different kinds of vaccines in versatile forms have been utilized to prevent virus infections, although the safety and effectiveness of these vaccines are diverse from each other. In this review, we first listed and described major pathogenic viruses and their pandemics that emerged in the past two centuries. Furthermore, we summarized the distinctive characteristics of different antiviral vaccines and adjuvants. Subsequently, in the main body, we reviewed recent advances of nanoparticles in the development of next-generation vaccines against influenza viruses, coronaviruses, HIV, hepatitis viruses, and many others. Specifically, we described applications of self-assembling protein polymers, virus-like particles, nano-carriers, and nano-adjuvants in antiviral vaccines. We also discussed the therapeutic potential of nanoparticles in developing safe and effective mucosal vaccines. Nanoparticle techniques could be promising platforms for developing broad-spectrum, preventive, or therapeutic antiviral vaccines.

Indexed as

adaptive immunityadjuvantinnate immunitynanoparticlevaccineviral infection

Identifiers

PMID38250843
PMCPMC10819235
OpenAlexW4390272278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.