Evidence map›Paper›PMID 38250835›Full record

ArticleVaccines2023

Humoral Immune Responses following COVID-19 Vaccinations among Adults in Tanzania.

Muhammad Bakari, Said Aboud, Mabula Kasubi, Bruno P Mmbando, Nyanda Elias Ntinginya, Aifello Sichalwe, Omary S Ubuguyu, Alex Magesa, Nancy Ladislaus Rutananukwa, Helmut Nyawale and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Muhammad BakariSchool of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam P.O. Box 65001, Tanzania.
Said AboudSchool of Medicine, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam P.O. Box 65001, Tanzania.
Mabula KasubiMuhimbili National Hospital (MNH), Dar es Salaam P.O. Box 65000, Tanzania.
Bruno P MmbandoNational Institute for Medical Research (NIMR), Dar es Salaam P.O. Box 9653, Tanzania.ORCID 0000-0001-7232-8708
Nyanda Elias NtinginyaNational Institute for Medical Research (NIMR), Dar es Salaam P.O. Box 9653, Tanzania.
Aifello SichalweMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Omary S UbuguyuMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Alex MagesaMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Nancy Ladislaus RutananukwaNational Institute for Medical Research (NIMR), Dar es Salaam P.O. Box 9653, Tanzania.ORCID 0000-0003-2016-964X
Helmut NyawaleDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences (CUHAS), Mwanza P.O. Box 1464, Tanzania.
Abisai KisindaNational Institute for Medical Research (NIMR), Dar es Salaam P.O. Box 9653, Tanzania.
Medard BeyangaMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Pius G HorumpendeMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Paulo S MhameMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Liggle M VumiliaMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Lucy S MzirayMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Reuben MkalaBenjamin Mkapa Hospital (BMH), Dodoma P.O. Box 11088, Tanzania.
Elichilia ShaoKilimanjaro Christian Medical Centre (KCMC), Moshi P.O. Box 3010, Tanzania.ORCID 0000-0003-3618-2822
Abel MakubiMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Stephen E MshanaDepartment of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences (CUHAS), Mwanza P.O. Box 1464, Tanzania.ORCID 0000-0002-7526-6271
Rogath KishimbaMinistry of Health (MoH), Dodoma P.O. Box 743, Tanzania.
Ministry of Health, Community Development, Gender, Elderly and Children · TZNational Institute for Medical Research · TZCatholic University of Health and Allied Sciences · TZMuhimbili University of Health and Allied Sciences · TZKilimanjaro Christian Medical Centre · TZMuhimbili National Hospital · TZTanzania National Parks · TZ

Funding

Ministry of Health Tanzania NA
6 · The paper itself

Abstract

COVID-19 vaccination remains to be the most important intervention in the fight against the pandemic. The immunity among the vaccinated population and its durability can significantly vary due to various factors. This study investigated the humoral immune responses among individuals who received any of the COVID-19 vaccines approved for use in Tanzania. A total of 1048 randomly selected adults who received COVID-19 vaccines at different time points were enrolled and humoral immune responses (IR) were tested at baseline and three months later (960, 91.6%). The level of SARS-CoV-2 anti-spike/receptor binding domain (RBD) IgG, anti-nucleocapsid IgG, and IgM antibodies were determined using a commercially available chemiluminescent microparticle immunoassay. Descriptive data analysis was performed using STATA version 18 and R. At baseline, serum IgG against anti-spike/RBD was detected in 1010/1048 (96.4%) participants (95%CI: 94.9-97.5) and 98.3% (95%CI: 97.3-99) three months later. The IgG against the SARS-CoV-2 nucleocapsid proteins were detected in 40.8% and 45.3% of participants at baseline and follow-up, respectively. The proportion of seroconverters following vaccination and mean titers of anti-spike/RBD antibodies were significantly more among those who had past SARS-CoV-2 infection than in those with no evidence of past infection, (

Indexed as

adultsCOVID-19 vaccineshumoral immune responseTanzania

Identifiers

PMID38250835
PMCPMC10819524
OpenAlexW4390176390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.