Evidence map›Paper›PMID 38250804›Full record

ArticleNon-coding RNA2023

Genetic Loss of miR-205 Causes Increased Mammary Gland Development.

Alessandra Cataldo, Douglas G Cheung, John P Hagan, Matteo Fassan, Sukhinder Sandhu-Deol, Carlo M Croce, Gianpiero Di Leva, Marilena V Iorio

Open access · goldAbstract read
In one paragraph

Article in Non-coding RNA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. MicroRNA-30a-3p Influences Milk Fat Metabolism by TargetingAnimals : an open access journal from MDPI · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Alessandra CataldoResearch Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.ORCID 0000-0002-1882-9410
Douglas G CheungComprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.
John P HaganDepartment of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.
Matteo FassanDepartment of Medicine, DIMED, University of Padua, 35122 Padua, Italy.ORCID 0000-0001-6515-5482
Sukhinder Sandhu-DeolComprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.
Carlo M CroceComprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.
Gianpiero Di LevaSchool of Pharmacy and Bioengineering, Keele University, Keele ST5 5BG, UK.
Marilena V IorioResearch Department, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
The Ohio State University · USFondazione IRCCS Istituto Nazionale dei Tumori · ITKeele University · GBThe University of Texas Health Science Center at Houston · USUniversity of Padua · IT

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
LIN28 and RNA Uridylation in Breast Cancer: Mouse Models and Molecular AnalysesR01CA215186 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HAGAN, JOHN PATRICK · 2017 to 2021
$1.7M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA215186NCI NIH HHS R01CA215186
6 · The paper itself

Abstract

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205

Indexed as

breast cancermammary glandmicroRNA

Identifiers

PMID38250804
PMCPMC10801544
OpenAlexW4390465733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.