Evidence map›Paper›PMID 38250801›Full record

ArticleNon-coding RNA2023

Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System.

Christopher Pai, Rajarshi Sengupta, Robert O Heuckeroth

Open access · goldAbstract read
In one paragraph

Article in Non-coding RNA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christopher PaiThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.ORCID 0000-0002-8504-3928
Rajarshi SenguptaAmerican Association for Cancer Research, Philadelphia, PA 19106, USA.
Robert O HeuckerothThe Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.ORCID 0000-0002-3282-1765
Children's Hospital of Philadelphia · USAmerican Association For Cancer Research · US

Funding

Children's Hospital of Philadelphia Center for Precision Dagnosis and Therapy for Pediatric Motility Disorders Frontier Program N/AChildren's Hospital of Philadelphia Research Institute N/AThe Irma and Norman Braman Endowment N/AThe Suzi and Scott Lustgarten Center Endowment N/A
6 · The paper itself

Abstract

The enteric nervous system (ENS) is an essential network of neurons and glia in the bowel wall. Defects in ENS development can result in Hirschsprung disease (HSCR), a life-threatening condition characterized by severe constipation, abdominal distention, bilious vomiting, and failure to thrive. A growing body of literature connects HSCR to alterations in miRNA expression, but there are limited data on the normal miRNA landscape in the developing ENS. We sequenced small RNAs (smRNA-seq) and messenger RNAs (mRNA-seq) from ENS precursor cells of mid-gestation

Indexed as

enteric nervous systemHirschsprung diseasemiR-124miR-137miR-27bmiR-488miR-9smRNA-seq

Identifiers

PMID38250801
PMCPMC10801555
OpenAlexW4390108871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.