Evidence map›Paper›PMID 38250663›Full record

ArticleInternational journal of inflammation2024

Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog,

Claire Lacombe, Estefania Aleman-Navaro, Thierry Drujon, Veronica Martinez-Osorio, Emmanuelle Sachon, Erika Melchy-Pérez, Ludovic Carlier, Lorena Elizabeth Fajardo Brigido, Yannick Fleury, Christophe Piesse and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of inflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Claire LacombeLaboratoire des Biomolécules, LBM, Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Paris, France.ORCID https://orcid.org/0000-0001-9428-8145
Estefania Aleman-NavaroInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Thierry DrujonLaboratoire des Biomolécules, LBM, Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Paris, France.ORCID https://orcid.org/0000-0002-9596-7550
Veronica Martinez-OsorioInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Emmanuelle SachonLaboratoire des Biomolécules, LBM, Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Paris, France.ORCID https://orcid.org/0000-0002-2271-8924
Erika Melchy-PérezInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0000-0002-8243-988X
Ludovic CarlierLaboratoire des Biomolécules, LBM, Sorbonne Université, École Normale Supérieure, PSL University, CNRS, Paris, France.ORCID https://orcid.org/0000-0002-9036-6561
Lorena Elizabeth Fajardo BrigidoInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Yannick FleuryLUBEM EA 3882, IUT Quimper, Université de Bretagne Occidentale, Quimper, France.ORCID https://orcid.org/0000-0002-1638-0963
Christophe PiessePlateforme de Synthèse Peptidique, Institut de Biologie Paris-Seine (ISBS), Sorbonne Université, CNRS, Paris, France.
Guadalupe Gutiérrez-EscobedoIPICYT, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, Mexico.
Alejandro De Las PeñasIPICYT, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, Mexico.
Irene CastañoIPICYT, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, Mexico.
Florie DesriacLUBEM EA 3882, IUT Quimper, Université de Bretagne Occidentale, Quimper, France.ORCID https://orcid.org/0000-0002-6436-6437
Jose Luis Beristain-HernandezHepatobiliary and Pancreatic Surgery Clinic, General Surgery Department La Raza National Medical Center, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.ORCID https://orcid.org/0000-0002-7628-2177
Christophe CombadiereSorbonne Université, Institut National de Santé et de Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS), Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.ORCID https://orcid.org/0000-0002-1755-4531
Yvonne RosensteinInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0000-0003-4040-4256
Constance AuvynetInstituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.ORCID https://orcid.org/0009-0000-3499-5593
Centre National de la Recherche Scientifique · FRUniversidad Nacional Autónoma de México · MXInstitute for Scientific and Technological Research · MXUniversité de Bretagne Occidentale · FRMexican Social Security Institute · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory and antimicrobial diseases constitute a major burden for society, and fighting them is a WHO strategic priority. Most of the treatments available to fight inflammatory diseases are anti-inflammatory drugs, such as corticosteroids or immunomodulators that lack cellular specificity and lead to numerous side effects. In addition to suppressing undesired inflammation and reducing disease progression, these drugs lessen the immune system protective functions. Furthermore, treating infectious diseases is more and more challenging due to the rise of microbial resistance to antimicrobial drugs. Thus, controlling the inflammatory process locally without compromising the ability to combat infections is an essential feature in the treatment of inflammatory diseases. We isolated three forms (DRS-DA2N, DRS-DA2NE, and DRS-DA2NEQ) of the same peptide, DRS-DA2, which belongs to the dermaseptin family, from the Mexican tree frog

Identifiers

PMID38250663
PMCPMC10799709
OpenAlexW4390837489

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.