Evidence map›Paper›PMID 38250661›Full record

ArticleFrontiers in physiology2023

Autophagy machinery plays an essential role in traumatic brain injury-induced apoptosis and its related behavioral abnormalities in mice: focus on

Livia Interdonato, Ylenia Marino, Daniela Impellizzeri, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Gaetano Cammilleri, Licia Pantano, Sergio Modafferi, Ali S Abdelhameed and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Livia Interdonato *Department of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Ylenia Marino *Department of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Daniela ImpellizzeriDepartment of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Ramona D'AmicoDepartment of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Rosalba SiracusaDepartment of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Roberta FuscoDepartment of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Gaetano CammilleriChemistry Department, Istituto Zooprofilattico Sperimentale Della Sicilia, Palermo, Italy.
Licia PantanoChemistry Department, Istituto Zooprofilattico Sperimentale Della Sicilia, Palermo, Italy.
Sergio ModafferiDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Ali S AbdelhameedDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Tilman FritschNAM-Institute, Salzburg, Austria.
Luay J RashanMedicinal Plants Division, Research Center, Dhofar University, Salalah, Oman.
Salvatore CuzzocreaDepartment of Chemical and Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Marika CordaroDepartment of Biomedical, Dental and Morphological and Functional Imaging University of Messina, Messina, Italy.
Rosanna Di PaolaDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
University of Messina · ITIstituto Zooprofilattico Sperimentale Della Sicilia · ITUniversity of Catania · ITDhofar University · OMKing Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is described as a structural damage or physiological disturbance of brain function that occurs after trauma and causes disability or death in people of all ages. New treatment targets for TBI are being explored because current medicines are frequently ineffectual and poorly tolerated. There is increasing evidence that following TBI, there are widespread changes in autophagy-related proteins in both experimental and clinical settings. The current study investigated if Boswellia Sacra Gum Resin (BSR) treatment (500 mg/kg) could modulate post-TBI neuronal autophagy and protein expression, as well as whether BSR could markedly improve functional recovery in a mouse model of TBI. Taken together our results shows for the first time that BSR limits histological alteration, lipid peroxidation, antioxidant, cytokines release and autophagic flux alteration induced by TBI.

Indexed as

apoptosisautophagybehavioralBoswellia sacraTBI

Identifiers

PMID38250661
PMCPMC10797063
OpenAlexW4390611735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.