Evidence map›Paper›PMID 38249623›Full record

ArticleCase reports in hepatology2024

Idiosyncratic Drug-Induced Liver Injury in a Healthy Patient following PCSK9-Inhibitor Injection.

B-O Stüben, D P Hoyer, S Radunz, F Saner, H Schmidt, H A Baba, J W Treckmann, L I Mazilescu

Abstract readCase Reports
In one paragraph

Article in Case reports in hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

B-O StübenDepartment of General, Visceral and Transplant Surgery, Medical Center University Duisburg-Essen, Essen 45147, Germany.ORCID https://orcid.org/0000-0001-8245-4548
D P HoyerDepartment of General, Visceral and Transplant Surgery, Medical Center University Duisburg-Essen, Essen 45147, Germany.
S RadunzDepartment of General, Visceral and Transplant Surgery, Medical Center University Duisburg-Essen, Essen 45147, Germany.
F SanerDepartment of General, Visceral and Transplant Surgery, Medical Center University Duisburg-Essen, Essen 45147, Germany.
H SchmidtDepartment of Internal Medicine, Medical Center University Duisburg-Essen, Essen 45147, Germany.
H A BabaInstitute of Pathology, Medical Center University Duisburg-Essen, Essen 45147, Germany.
J W TreckmannDepartment of General, Visceral and Transplant Surgery, Medical Center University Duisburg-Essen, Essen 45147, Germany.
L I MazilescuDepartment of General, Visceral and Transplant Surgery, Medical Center University Duisburg-Essen, Essen 45147, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute liver injury is a life-threatening condition with disparate aetiology. Swift and adequate interdisciplinary treatment is essential to assure the best possible outcomes in these patients. Investigations to identify the cause of the condition and the implementation of quick and appropriate treatment can be lifesaving. Conclusion: This is to our knowledge the first reported acute liver injury due to an inclisiran injection. Cortisol in combination with OPAL dialysis is an effective method for the treatment of acute liver injury caused by inclisiran injury, and in this case, it led to a near-complete reversal of the acute liver injury at the time of discharge.

Identifiers

PMID38249623
PMCPMC10796182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.