Evidence map›Paper›PMID 38249464›Full record

ArticleFrontiers in microbiology2023

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain.

Mengli Chen, Lei Kang, Tong Zhang, Jiayang Zheng, Dishi Chen, Donghua Shao, Zongjie Li, Beibei Li, Jianchao Wei, Yafeng Qiu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Animal virus-host interactions mediated by non-coding RNAs.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Mengli ChenShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Lei KangShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Tong ZhangShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Jiayang ZhengShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Dishi ChenSichuan Animal Disease Prevention and Control Center, Chengdu, China.
Donghua ShaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Zongjie LiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Beibei LiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Jianchao WeiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Yafeng QiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Xiuli FengKey Laboratory of Animal Disease Diagnostic and Immunology, Department of Veterinary Medicine College, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Zhiyong MaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Ke LiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China.
Shanghai Veterinary Research Institute · CNNanjing Agricultural University · CNSichuan Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Japanese encephalitis is one of the most important insect-borne infectious disease with public health concern. The virus can break the blood-brain barrier and cause death or long-term sequela in infected humans or animals. Viral encephalitis is an important clinical feature of JEV infection. In recent studies, CircRNAs and related ceRNAs data illustrated the regulative role in many aspects of biological process and disease duration. It is believed that CircRNA regulates JEV infection in a ceRNA-dependent mechanism. In this study, brain tissues of experimental mice were sequenced and analysised. 61 differentially expressed circRNAs, 172 differentially expressed miRNAs and 706 differentially expressed mRNAs were identified by RNA-Sequencing and statistical analysis. CX3CR1 was determined as a key host factor impact JEV infection by microRNA interference measurement. CX3CR1 interaction network indicated circStrbp/miR709/CX3CR1 as a functional regulation axis. Further sequencing in BV2 cell shown CX3CR1 is a special target of miR-709 only during JEV infection. In summary, our study presented a new ceRNA pathway that impact JEV infection

Indexed as

ceRNAcircular RNAJapanese encephalitisJapanese encephalitis virusmiR-709

Identifiers

PMID38249464
PMCPMC10797004
OpenAlexW4390611731

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.