Evidence map›Paper›PMID 38249440›Full record

ArticleComputer methods in applied mechanics and engineering2023

Image-guided subject-specific modeling of glymphatic transport and amyloid deposition.

Michael J Johnson, Michael R A Abdelmalik, Frimpong A Baidoo, Andrew Badachhape, Thomas J R Hughes, Shaolie S Hossain

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computer methods in applied mechanics and engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Michael J JohnsonOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 E. 24th St, Austin, Texas 78712, USA.
Michael R A AbdelmalikDepartment of Mechanical Engineering, Eindhoven University of Technology, Gemini, Building number 15, Groene Loper, 5612 AE Eindhoven, The Netherlands.
Frimpong A BaidooOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 E. 24th St, Austin, Texas 78712, USA.
Andrew BadachhapeDepartment of Radiology, Baylor College of Medicine, 701 Fannin Street, Suite 47, Houston, Texas 77030, USA.
Thomas J R HughesOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 E. 24th St, Austin, Texas 78712, USA.
Shaolie S HossainOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, 201 E. 24th St, Austin, Texas 78712, USA.
The University of Texas at Austin · USBaylor College of Medicine · USEindhoven University of Technology · NLHouston Methodist · US

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
A mechanistic understanding of glymphatic transport and its implications in neurodegenerative diseaseR21AG080207 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI HOSSAIN, SHAOLIE SAMIRA · 2023 to 2023
$438k
NIA NIH HHS R21 AG080207NIBIB NIH HHS P41 EB015897
6 · The paper itself

Abstract

The glymphatic system is a brain-wide system of perivascular networks that facilitate exchange of cerebrospinal fluid (CSF) and interstitial fluid (ISF) to remove waste products from the brain. A greater understanding of the mechanisms for glymphatic transport may provide insight into how amyloid beta (

Indexed as

Alzheimer’s diseasehierarchical meshingimmersed methodisogeometric analysisneurodegeneration

Identifiers

PMID38249440
PMCPMC10798618
OpenAlexW4387098509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.