Evidence map›Paper›PMID 38248654›Full record

ArticleMarine drugs2023

Chlorinated Enyne Fatty Acid Amides from a Marine Cyanobacterium: Discovery of Taveuniamides L-M and Pharmacological Characterization of Taveuniamide F as a GPCR Antagonist with CNR1 Selectivity.

Lobna A Elsadek, Emma K Ellis, Gustavo Seabra, Valerie J Paul, Hendrik Luesch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Marine natural products.Natural product reports · 2026
    Review
  2. Review
  3. Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lobna A ElsadekDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.
Emma K EllisDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0002-0819-8598
Gustavo SeabraDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0002-1303-4483
Valerie J PaulSmithsonian Marine Station, 701 Seaway Drive, Fort Pierce, FL 34949, USA.ORCID 0000-0002-4691-1569
Hendrik LueschDepartment of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.ORCID 0000-0002-4091-7492
University of Florida · USSmithsonian Marine Station · US

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
Chemistry-Biology Interface Training Program at the University of FloridaT32GM136583 · NIGMS · UNIVERSITY OF FLORIDA · PI Chenglong Li · 2020 to 2026
$1.1M
NMR console upgrade for structural biology and metabolomicsS10OD028753 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2020 to 2020
$600k
Discovery and Mechanistic Characterization of New Cytotoxic Agents from Marine CyanobacteriaF31GM143915 · NIGMS · UNIVERSITY OF FLORIDA · PI ELSADEK, LOBNA · 2021 to 2022
$89k
NCI NIH HHS R01 CA172310NIGMS NIH HHS F31 GM143915NIGMS NIH HHS T32 GM136583NIH HHS F31GM143915NIH HHS R01CA172310NIH HHS S10 OD028753NIH HHS T32GM136583
6 · The paper itself

Abstract

NMR and MS/MS-based metabolomics of a cyanobacterial extract from Piti Bomb Holes, Guam, indicated the presence of unique enyne-containing halogenated fatty acid amides. We isolated three new compounds of this class, taveuniamides L-N (

Indexed as

CyanobacteriaDrug Inverse AgonismAmidesFatty AcidsTandem Mass SpectrometryAmidesFatty Acidschlorinated enyneCNR1cyanobacteriafatty acid amidesGPCR

Identifiers

PMID38248654
PMCPMC10817531
OpenAlexW4390467837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.