Evidence map›Paper›PMID 38248647›Full record

ArticleMarine drugs2023

OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived

Yanqing Li, Naying Gong, Le Zhou, Zhijie Yang, Hua Zhang, Yucheng Gu, Junying Ma, Jianhua Ju

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yanqing LiCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Naying GongGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China.
Le ZhouCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Zhijie YangCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Hua ZhangGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Guangdong Medical University, Dongguan 523808, China.
Yucheng GuSyngenta Jealott's Hill International Research Centre, Bracknell RG42 6EY, Berkshire, UK.ORCID 0000-0002-6400-6167
Junying MaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.ORCID 0000-0002-0641-7291
Jianhua JuCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.ORCID 0000-0001-7712-8027
Chinese Academy of Sciences · CNGuangdong Medical College · CNSyngenta (United Kingdom) · GB

Funding

Fundamental Research & Applied Fundamental Research Major Project of Guangdong Province 2019B030302004Key Science and Technology Project of Hainan Province (ZDKJ202018)Local Innovation and Entrepreneurship Team Project of Guangdong 2019BT02Y262Open Program of Shen Zhen Bay Laboratory SZBL2021080601006the Nansha District Science and Technology Plan Project NSJL202102the National Natural Science Foundation of China 82022067, 22037006, 31870046the Rising Star Foundation of the South China Sea Institute of Oceanology NHXX2019SW0101
6 · The paper itself

Abstract

The one strain many compounds (OSMAC) strategy is an effective method for activating silent gene clusters by cultivating microorganisms under various conditions. The whole genome sequence of the marine-derived strain

Indexed as

Multigene FamilyStreptomycesAnti-Bacterial AgentsBenz(a)AnthracenesHumansAnti-Bacterial AgentsBenz(a)Anthracenesmayamycinangucyclinesbiosynthetic gene clusters (BGCs)OSMACstreptophenazinestumor cytotoxic activity

Identifiers

PMID38248647
PMCPMC10817512
OpenAlexW4390347716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.