Evidence map›Paper›PMID 38248319›Full record

ArticleCurrent issues in molecular biology2023

Characterization of the mIF4G Domains in the RNA Surveillance Protein Upf2p.

Edgardo M Colón, Luis A Haddock, Clarivel Lasalde, Qishan Lin, Juan S Ramírez-Lugo, Carlos I González

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Edgardo M ColónDepartment of Biology, Río Piedras Campus, University of Puerto Rico, San Juan, PR 00931, USA.ORCID 0000-0003-4183-9729
Luis A HaddockDepartment of Biology, Río Piedras Campus, University of Puerto Rico, San Juan, PR 00931, USA.ORCID 0000-0001-8916-5693
Clarivel LasaldeDepartment of Biology, Río Piedras Campus, University of Puerto Rico, San Juan, PR 00931, USA.
Qishan LinDepartment of Chemistry, University at Albany, Albany, NY 12222, USA.ORCID 0000-0002-1756-1432
Juan S Ramírez-LugoDepartment of Biology, Río Piedras Campus, University of Puerto Rico, San Juan, PR 00931, USA.
Carlos I GonzálezDepartment of Biology, Río Piedras Campus, University of Puerto Rico, San Juan, PR 00931, USA.
University of Puerto Rico at Río Piedras · PRUniversity at Albany, State University of New York · US

Funding

Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
Annual Meeting of the NCRR P41 Principal InvestigatorsU13RR016174 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2001 to 2005
$378k
NCRR NIH HHS U13 RR016174NIGMS NIH HHS R25 GM061151NIH HHS 5R25GM061151
6 · The paper itself

Abstract

Thirty percent of all mutations causing human disease generate mRNAs with premature termination codons (PTCs). Recognition and degradation of these PTC-containing mRNAs is carried out by the mechanism known as nonsense-mediated mRNA decay (NMD). Upf2 is a scaffold protein known to be a central component of the NMD surveillance pathway. It harbors three middle domains of eukaryotic initiation factor 4G (mIF4G-1, mIF4G-2, mIF4G-3) in its N-terminal region that are potentially important in regulating the surveillance pathway. In this study, we defined regions within the mIF4G-1 and mIF4G-2 that are required for proper function of Upf2p in NMD and translation termination in

Indexed as

aspartic acidcloningcodoneukaryotic initiation factor-4Gmolecularnonsensenonsense-mediated mRNA decaySaccharomyces cerevisiae

Identifiers

PMID38248319
PMCPMC10814901
OpenAlexW4390404977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.