Evidence map›Paper›PMID 38248309›Full record

ArticleBrain sciences2024

Brain Frontal-Lobe Misery Perfusion in COVID-19 ICU Survivors: An MRI Pilot Study.

Jie Song, Shivalika Khanduja, Hannah Rando, Wen Shi, Kaisha Hazel, George Paul Pottanat, Ebony Jones, Cuimei Xu, Zhiyi Hu, Doris Lin and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jie SongDepartment of Biomedical Engineering, Johns Hopkins University School of Engineering, Baltimore, MD 21218, USA.ORCID 0009-0004-8533-5893
Shivalika KhandujaDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Hannah RandoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Wen ShiDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-5312-4889
Kaisha HazelThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Park 324, Baltimore, MD 21287, USA.
George Paul PottanatThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Park 324, Baltimore, MD 21287, USA.
Ebony JonesThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Park 324, Baltimore, MD 21287, USA.
Cuimei XuThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Park 324, Baltimore, MD 21287, USA.
Zhiyi HuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Doris LinThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Park 324, Baltimore, MD 21287, USA.ORCID 0000-0002-6001-2383
Sevil YasarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Hanzhang LuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sung-Min ChoDepartment of Neurology, Neurosurgery, Surgery, Anesthesiology, and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-5132-0958
Dengrong JiangThe Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Park 324, Baltimore, MD 21287, USA.ORCID 0000-0002-3843-1020
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Validation of small vessel vascular contributions to cognitive impairment and dementia (VCID) biomarkersU01NS100588 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., LU, HANZHANG · 2023 to 2025
$4.1M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's diseaseR01AG064792 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2020 to 2023
$2.6M
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal modelsRF1AG071515 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2021 to 2021
$2.4M
Physiological imaging markers in vascular contributions to cognitive impairment and dementia (VCID)R01AG085299 · NIA · JOHNS HOPKINS UNIVERSITY · PI Hanzhang Lu · 2024 to 2026
$2.3M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
MRI assessment of cerebral oxygen extraction fraction (OEF) in the medial temporal lobe as a biomarker in Alzheimer's diseaseR21AG079098 · NIA · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2022 to 2022
$450k
NIA NIH HHS R01 AG064792NIA NIH HHS R01 AG085299NIA NIH HHS R21 AG079098NIA NIH HHS RF1 AG071515NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103538NIH HHS P41 EB031771NIH HHS R01 AG064792NIH HHS R01 AG085299NIH HHS R01 NS106702NIH HHS R01 NS106711NIH HHS R21 AG079098NIH HHS RF1 AG071515NIH HHS U01 NS100588NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711NINDS NIH HHS U01 NS100588
6 · The paper itself

Abstract

Post-acute COVID-19 syndrome (PCS) is highly prevalent. Critically ill patients requiring intensive care unit (ICU) admission are at a higher risk of developing PCS. The mechanisms underlying PCS are still under investigation and may involve microvascular damage in the brain. Cerebral misery perfusion, characterized by reduced cerebral blood flow (CBF) and elevated oxygen extraction fraction (OEF) in affected brain areas, has been demonstrated in cerebrovascular diseases such as carotid occlusion and stroke. This pilot study aimed to examine whether COVID-19 ICU survivors exhibited regional misery perfusion, indicating cerebral microvascular damage. In total, 7 COVID-19 ICU survivors (4 female, 20-77 years old) and 19 age- and sex-matched healthy controls (12 female, 22-77 years old) were studied. The average interval between ICU admission and the MRI scan was 118.6 ± 30.3 days. The regional OEF was measured using a recently developed technique, accelerated T

Indexed as

cerebral blood flowcerebral microvascular damageCOVID-19ICUmisery perfusionoxygen extraction fractionpost-acute COVID-19 syndrome

Identifiers

PMID38248309
PMCPMC10813864
OpenAlexW4390986326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.