Evidence map›Paper›PMID 38248103›Full record

ArticleCurrent oncology (Toronto, Ont.)2024

Genetic Polymorphisms and Tumoral Mutational Profiles over Survival in Advanced Colorectal Cancer Patients: An Exploratory Study.

Juan Pablo Cayún, Leslie Carol Cerpa, Alicia Colombo, Dante Daniel Cáceres, José Luis Leal, Felipe Reyes, Carolina Gutiérrez-Cáceres, Susan Calfunao, Nelson Miguel Varela, Luis Abel Quiñones

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Can Asiatic Acid fromCancers · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Juan Pablo CayúnLaboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.ORCID 0000-0003-3781-7092
Leslie Carol CerpaLaboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.
Alicia ColomboAnatomy Pathology Service, Hospital Clínico de la Universidad de Chile, Santiago 8350499, Chile.ORCID 0000-0002-2690-146X
Dante Daniel CáceresInstitute of Population Health, School of Public Health, Faculty of Medicine, University of Chile, Santiago 8350499, Chile.
José Luis LealCancer Research Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago 8350499, Chile.
Felipe ReyesCancer Research Department, Instituto Oncológico Fundación Arturo López Pérez, Santiago 8350499, Chile.
Carolina Gutiérrez-CáceresLaboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.
Susan CalfunaoLaboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.
Nelson Miguel VarelaLaboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.ORCID 0000-0002-5229-3007
Luis Abel QuiñonesLaboratory of Chemical Carcinogenesis and Pharmacogenetics, Department of Basic-Clinical Oncology (DOBC), Faculty of Medicine, University of Chile, Santiago 8350499, Chile.ORCID 0000-0002-7967-5320
University of Chile · CLFundación Arturo López Pérez · CLHospital Clínico de la Universidad de Chile · CLHospital Luis Calvo Mackenna · CL

Funding

Agencia Nacional de Investigación y Desarrollo 1211948
6 · The paper itself

Abstract

Colorectal cancer is a common disease, both in Chile and worldwide. The most widely used chemotherapy schemes are based on 5-fluorouracil (5FU) as the foundational drug (FOLFOX, CapeOX). Genetic polymorphisms have emerged as potential predictive biomarkers of response to chemotherapy, but conclusive evidence is lacking. This study aimed to investigate the role of genetic variants associated with 5FU-based chemotherapy on therapeutic response, considering their interaction with oncogene mutations (

Indexed as

Colorectal NeoplasmsProto-Oncogene Proteins B-rafBiomarkersFluorouracilHumansMutationRetrospective StudiesBiomarkersFluorouracilProto-Oncogene Proteins B-rafbiomarkerscolorectal cancerpharmacogenomics

Identifiers

PMID38248103
PMCPMC10814806
OpenAlexW4390538085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.