Evidence map›Paper›PMID 38248061›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Motion Contrast, Phase Gradient, and Simultaneous OCT Images Assist in the Interpretation of Dark-Field Images in Eyes with Retinal Pathology.

Mircea Mujat, Konstantina Sampani, Ankit H Patel, Ronald Zambrano, Jennifer K Sun, Gadi Wollstein, R Daniel Ferguson, Joel S Schuman, Nicusor Iftimia

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mircea MujatPhysical Sciences, Inc., 20 New England Business Center, Andover, MA 01810, USA.ORCID 0000-0002-9670-420X
Konstantina SampaniBeetham Eye Institute, Joslin Diabetes Center, Boston, MA 02115, USA.ORCID 0000-0002-6570-328X
Ankit H PatelPhysical Sciences, Inc., 20 New England Business Center, Andover, MA 01810, USA.
Ronald ZambranoDepartment of Ophthalmology, New York University School of Medicine, New York, NY 10017, USA.
Jennifer K SunBeetham Eye Institute, Joslin Diabetes Center, Boston, MA 02115, USA.
Gadi WollsteinDepartment of Ophthalmology, New York University School of Medicine, New York, NY 10017, USA.
R Daniel FergusonPhysical Sciences, Inc., 20 New England Business Center, Andover, MA 01810, USA.
Joel S SchumanWills Eye Hospital, Philadelphia, PA 19107, USA.ORCID 0000-0002-8885-3766
Nicusor IftimiaPhysical Sciences, Inc., 20 New England Business Center, Andover, MA 01810, USA.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 DiabetesR44DK113932 · NIDDK · PHYSICAL SCIENCES, INC · PI MUJAT, MIRCEA · 2017 to 2019
$1.3M
Multi-modal AO-LSO Phase Gradient Imaging of the Inner RetinaR44EY023481 · NEI · PHYSICAL SCIENCES, INC · PI MUJAT, MIRCEA · 2018 to 2019
$1.0M
NEI NIH HHS R01 EY013178NEI NIH HHS R44 EY023481NEI NIH HHS R44EY023481 and R01-EY013178NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R44 DK113932NIDDK NIH HHS R44DK113932
6 · The paper itself

Abstract

The cellular-level visualization of retinal microstructures such as blood vessel wall components, not available with other imaging modalities, is provided with unprecedented details by dark-field imaging configurations; however, the interpretation of such images alone is sometimes difficult since multiple structural disturbances may be present in the same time. Particularly in eyes with retinal pathology, microstructures may appear in high-resolution retinal images with a wide range of sizes, sharpnesses, and brightnesses. In this paper we show that motion contrast and phase gradient imaging modalities, as well as the simultaneous acquisition of depth-resolved optical coherence tomography (OCT) images, provide additional insight to help understand the retinal neural and vascular structures seen in dark-field images and may enable improved diagnostic and treatment plans.

Indexed as

adaptive opticsdiabetic retinopathyoptical coherence tomographyretinal diseasescanning laser ophthalmoscopy

Identifiers

PMID38248061
PMCPMC10814023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.