Evidence map›Paper›PMID 38247827›Full record

ReviewCells2024

Cellular Strategies for Separating GvHD from GvL in Haploidentical Transplantation.

Mauro Di Ianni, Carmine Liberatore, Nicole Santoro, Paola Ranalli, Francesco Guardalupi, Giulia Corradi, Ida Villanova, Barbara Di Francesco, Stefano Lattanzio, Cecilia Passeri and 2 more

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mauro Di IanniHematology Unit, Pescara Hospital, 65124 Pescara, Italy.ORCID 0000-0002-6701-4023
Carmine LiberatoreHematology Unit, Pescara Hospital, 65124 Pescara, Italy.ORCID 0000-0003-0948-9343
Nicole SantoroHematology Unit, Pescara Hospital, 65124 Pescara, Italy.
Paola RanalliHematology Unit, Pescara Hospital, 65124 Pescara, Italy.
Francesco GuardalupiDepartment of Medicine and Aging Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Giulia CorradiDepartment of Medicine and Aging Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Ida VillanovaBlood Bank Unit, Pescara Hospital, 65124 Pescara, Italy.ORCID 0009-0001-8606-1183
Barbara Di FrancescoBlood Bank Unit, Pescara Hospital, 65124 Pescara, Italy.
Stefano LattanzioDepartment of Medicine and Aging Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Cecilia PasseriBlood Bank Unit, Pescara Hospital, 65124 Pescara, Italy.
Paola LanutiDepartment of Medicine and Aging Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-4197-9780
Patrizia AccorsiBlood Bank Unit, Pescara Hospital, 65124 Pescara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GvHD still remains, despite the continuous improvement of transplantation platforms, a fearful complication of transplantation from allogeneic donors. Being able to separate GvHD from GvL represents the greatest challenge in the allogeneic transplant setting. This may be possible through continuous improvement of cell therapy techniques. In this review, current cell therapies are taken into consideration, which are based on the use of TCR alpha/beta depletion, CD45RA depletion, T regulatory cell enrichment, NK-cell-based immunotherapies, and suicide gene therapies in order to prevent GvHD and maximally amplify the GvL effect in the setting of haploidentical transplantation.

Indexed as

Cell- and Tissue-Based TherapyTransplantation, HaploidenticalFearHumansImmunotherapyKiller Cells, NaturalCD45RAGvHDGvLimmunotherapiesNKsuicide geneTCR alpha-betaTregs

Identifiers

PMID38247827
PMCPMC10814899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.