Evidence map›Paper›PMID 38247803›Full record

ArticleCells2024

A Novel Protozoa Parasite-Derived Protein Adjuvant Is Effective in Immunization with Cancer Cells to Activate the Cancer-Specific Protective Immunity and Inhibit the Cancer Growth in a Murine Model of Colorectal Cancer.

Rajesh Mani, Chloe G Martin, Kanal E Balu, Qingding Wang, Piotr Rychahou, Tadahide Izumi, B Mark Evers, Yasuhiro Suzuki

Open access · goldAbstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Computational vaccine development against protozoa.Computational and structural biotechnology journal · 2025
    Review
  12. Culture supernatant ofOncology letters · 2025
    Article
  13. Parasites revive hope for cancer therapy.European journal of medical research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rajesh ManiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
Chloe G MartinDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
Kanal E BaluDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
Qingding WangDepartment of Surgery, University of Kentucky, Lexington, KY 40536, USA.ORCID 0009-0002-4797-4876
Piotr RychahouDepartment of Surgery, University of Kentucky, Lexington, KY 40536, USA.
Tadahide IzumiMarkey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0003-4855-8436
B Mark EversDepartment of Surgery, University of Kentucky, Lexington, KY 40536, USA.
Yasuhiro SuzukiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
University of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
Cooperation of CD8+ T cells and phagocytes to eliminate Toxoplasma cystsR01AI095032 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2012 to 2023
$4.1M
NCI NIH HHS P30 CA177558NIAID NIH HHS R01 AI095032
6 · The paper itself

Abstract

Cancer-specific CD8

Indexed as

Colorectal NeoplasmsParasitesAdjuvants, ImmunologicAdjuvants, PharmaceuticAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalImmunizationMiceAdjuvants, ImmunologicAdjuvants, Pharmaceuticcancer immunotherapyCD8+ T cellscytotoxic activityIFN-γintratumoral T cellsprotein adjuvantToxoplasma gondii

Identifiers

PMID38247803
PMCPMC10814441
OpenAlexW4390664001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.