Evidence map›Paper›PMID 38247783›Full record

ArticleGels (Basel, Switzerland)2024

Alginate Gel Encapsulated with Enzybiotics Cocktail Is Effective against Multispecies Biofilms.

Daria V Vasina, Nataliia P Antonova, Elena V Shidlovskaya, Nadezhda A Kuznetsova, Alexander V Grishin, Elizaveta A Akoulina, Ekaterina A Trusova, Anastasiya M Lendel, Elena P Mazunina, Sofia R Kozlova and 4 more

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Daria V VasinaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0003-1965-0700
Nataliia P AntonovaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0001-7025-8056
Elena V ShidlovskayaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Nadezhda A KuznetsovaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-7399-7628
Alexander V GrishinN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-1436-9015
Elizaveta A AkoulinaFaculty of Biology, MSU-BIT Shenzhen University, Shenzhen 518115, China.ORCID 0000-0002-2560-624X
Ekaterina A TrusovaFaculty of Biology, MSU-BIT Shenzhen University, Shenzhen 518115, China.
Anastasiya M LendelN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0009-0007-8439-6370
Elena P MazuninaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.ORCID 0000-0003-0701-5152
Sofia R KozlovaN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Andrei A DudunResearch Center of Biotechnology of the Russian Academy of Sciences Leninsky Ave, 33, Bld. 2, 119071 Moscow, Russia.ORCID 0000-0002-3307-7923
Anton P BonartsevFaculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.ORCID 0000-0001-5894-9524
Vladimir G LuninN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Vladimir A GushchinN.F. Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Ministry of Health of the Russian Federation · RULomonosov Moscow State University · RUShenzhen University · CNRussian Academy of Sciences · RU

Funding

Russian Science Foundation 23-74-10027
6 · The paper itself

Abstract

The development of new and effective antibacterials for pharmaceutical or cosmetic skin care that have a low potential for the emergence and expansion of bacterial resistance is of high demand in scientific and applied research. Great hopes are placed on alternative agents such as bactericidal peptidoglycan hydrolases, depolymerases, etc. Enzybiotic-based preparations are being studied for the treatment of various infections and, among others, can be used as topical formulations and dressings with protein-polysaccharide complexes. Here, we investigate the antibiofilm properties of a novel enzybiotic cocktail of phage endolysin LysSi3 and bacteriocin lysostaphin, formulated in the alginate gel matrix and its ability to control the opportunistic skin-colonizing bacteria

Indexed as

alginate gelbiofilmsendolysinenzybioticslysostaphinpolymicrobial infection

Identifiers

PMID38247783
PMCPMC10815372
OpenAlexW4390876650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.