ArticleGels (Basel, Switzerland)2024
Studies on Loading Salicylic Acid in Xerogel Films of Crosslinked Hyaluronic Acid.
Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- From acidification to multi-targeted cellular modulation: dual impact of hydroxy acids on the skin microbiota and the epidermal barrier.Frontiers in cellular and infection microbiology · 2026Review
- Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase-2 Inhibitor.ChemMedChem · 2025Article
- Antibody-Integrated Solid-to-Gel Microfilm for Protection Against Botulinum Neurotoxin Type A.Gels (Basel, Switzerland) · 2025Article
- Crosslinking by Click Chemistry of Hyaluronan Graft Copolymers Involving Resorcinol-Based Cinnamate Derivatives Leading to Gel-like Materials.Gels (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decades, salicylic acid (SA) and hyaluronic acid (HA) have been studied for a wide range of cosmetic and pharmaceutical applications. The current study investigated the drug loading potential of SA in HA-based crosslinked hydrogel films using a post-loading (osmosis) method of the unmedicated xerogels from saturated aqueous solutions of salicylic acid over a range of pH values. The films were characterized with Fourier-transform infra-red spectroscopy (FT-IR) and ultraviolet-visible (UV-Vis) spectrophotometry in order to elucidate the drug loading profile and the films' integrity during the loading process. Additional studies on their weight loss (%), gel fraction (%), thickness increase (%) and swelling (%) were performed. Overall, the studies showed significant film disintegration at highly acidic and basic solutions. No drug loading occurred at neutral and basic pH, possibly due to the anionic repulsion between SA and HA, whereas at, pH 2.1, the drug loading was promising and could be detected via UV-Vis analysis of the medicated solutions, with the SA concentration in the xerogel films at 28%
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Registered trials
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