Evidence map›Paper›PMID 38247735›Full record

ArticleGels (Basel, Switzerland)2023

Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications.

Enrico Gallo, Carlo Diaferia, Sabrina Giordano, Elisabetta Rosa, Barbara Carrese, Gennaro Piccialli, Nicola Borbone, Giancarlo Morelli, Giorgia Oliviero, Antonella Accardo

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Enrico GalloIRCCS SYNLAB SDN, Via Gianturco 113, 80143 Naples, Italy.ORCID 0000-0002-6132-4143
Carlo DiaferiaDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-9273-0136
Sabrina GiordanoIRCCS SYNLAB SDN, Via Gianturco 113, 80143 Naples, Italy.
Elisabetta RosaDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Barbara CarreseIRCCS SYNLAB SDN, Via Gianturco 113, 80143 Naples, Italy.ORCID 0000-0002-5867-4775
Gennaro PiccialliDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Nicola BorboneDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0003-0216-9814
Giancarlo MorelliDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.
Giorgia OlivieroDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.ORCID 0000-0003-0765-2127
Antonella AccardoDepartment of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-7899-2359

Funding

Italian Ministry of University and Research 2022TSLMHRMinistero della Salute Progetto Ricerca Corrente
6 · The paper itself

Abstract

Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical applications. Our knowledge of the molecular determinants of Fmoc-FF aggregation is used as a guide to design new peptide-based gelators, with features for the development of improved tools. Here, we enlarge the plethora of Fmoc-FF-based hydrogelated matrices by studying the properties of the Fmoc-FFK tripeptide, alone or in combination with Fmoc-FF. For multicomponent matrices, the relative weight ratios between Fmoc-FFK and Fmoc-FF (specifically, 1/1, 1/5, 1/10, and 1/20

Indexed as

cationic peptideFmoc-FF analogueshydrogelspeptide materialssoft materials

Identifiers

PMID38247735
PMCPMC10815546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.