Conundrums in the Management of Febrile Infants under Three Months of Age and Future Research.

Helena Wilcox, Etimbuk Umana, Emmanuelle Fauteux-Lamarre, Roberto Velasco, Thomas Waterfield

Abstract readReview

In one paragraph

Review in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Performance of clinical decision aids (CDA) for the care of young febrile infants: a multicentre prospective cohort study conducted in the UK and Ireland.EClinicalMedicine · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Helena WilcoxSt. Georges University Hospital NHS Foundation Trust, London SW17 0QT, UK.

Etimbuk UmanaWellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.ORCID 0000-0002-0780-8614

Emmanuelle Fauteux-LamarreEmergency Department, Cork University Hospital, Wilton, T12 DC4A Cork, Ireland.

Roberto VelascoPediatric Emergency Unit, Hospital Universitari Parc Tauli, Institut d'Investigació i Innovació I3PT, 08208 Sabadell, Spain.ORCID 0000-0003-0073-2650

Thomas WaterfieldWellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Febrile infants under three months of age pose a diagnostic challenge to clinicians. Unlike in older children, the rates of invasive bacterial infections (IBIs), such as bacteraemia or meningitis, are high. This greater risk of IBI combined with the practical challenges of assessing young infants results in a cautious approach with many febrile infants receiving parenteral antibiotics "just in case". However, there is a range of validated tailored care guidelines that support targeted investigation and management of febrile infants, with a cohort identified as lower risk suitable for fewer invasive procedures and observation without parenteral antibiotics. This manuscript outlines five common conundrums related to the safe application of tailored-care guidelines for the assessment and management of febrile infants under three months of age. It also explores future research which aims to further refine the management of febrile infants.

Indexed as

bacterial infectionfebrile infanturinary tract infection

Identifiers

PMID38247647

DOI10.3390/antibiotics13010088

PMCPMC10812496

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.