ArticleJournal of global health2024
The congenital birth defects burden in children younger than 14 years of age, 1990 - 2019: An age-period-cohort analysis of the global burden of disease study.
Article in Journal of global health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Sex differences in global burden of Congenital Heart Anomalies in children under five from 1990 to 2021.PloS one · 2026Article
- Global burden of diarrheal diseases attributable to 13 pathogens in children under five: a comprehensive analysis from GBD 2021.Frontiers in pediatrics · 2026Article
- Medical genetics needs assessment: An online cross-sectional survey from Nepal.Genetics in medicine open · 2026Article
- Analyzing the global burden of 11 subtypes of congenital birth defects: trends, sociodemographic correlates, and outcomes from 1990 to 2021.Annals of medicine · 2025Article
- Trends of infectious diseases, epidemic patterns, and the association with meteorological events: 2500 years of evidence from an observational study.Journal of global health · 2025Observational
- Comparative performance and health economic analysis of prenatal screening for down syndrome in Fujian province, China.Scientific reports · 2025Article
- Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040.BMC pregnancy and childbirth · 2025Article
- Global, regional, and national epidemiology of congenital birth defects in children from 1990 to 2021: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Global, regional and national burden and time trends of malaria in children and young adolescents under 15 years from 1990 to 2021: a worldwide observational study.BMC infectious diseases · 2025Observational
- Emerging trends and cross-country health inequalities in congenital birth defects: insights from the GBD 2021 study.International journal for equity in health · 2025Article
- Single-Cell RNA sequencing reveals mitochondrial dysfunction in microtia chondrocytes.Scientific reports · 2025Article
- The influence and lag-effect of temperature and precipitation on the incidence and mortality of tuberculosis, 2000-2021: an observational study.Frontiers in public health · 2025Observational
- Spatial Epidemiologic Analysis of Fetal Birth Defects in Guangxi, China.International journal of general medicine · 2025Article
- Burden of Non‑Communicable Diseases Among Children and Adolescents in the Asia‑Pacific Region, 1990-2021: Analysis for the Global Burden of Diseases Study 2021.Annals of global health · 2025Article
- Article
- Burden and trends of infectious disease mortality attributed to air pollution, unsafe water, sanitation, and hygiene, and non-optimal temperature globally and in different socio-demographic index regions.Global health research and policy · 2024Observational
- Trend of Mortality Due to Congenital Anomalies in Children Younger Than 5 Years in Eastern China, 2012-2021: Surveillance Data Analysis.JMIR public health and surveillance · 2024Article
- Birth Defects and Mortality-Related Factors in Colombia: Insights from a Surveillance Cohort (2002-2019).Sage open pediatricsArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aims to delineate the burden of congenital birth defects (CBDs) in children under 14 years of age from 1990 to 2019, using an age-period-cohort framework to analyse data from the Global Burden of Disease Study (GBD). Methods: Data on prevalence cases, age-standardised prevalence rates (ASPRs), death cases, and age-standardised death rates (ASDRs) of congenital birth defects (CBDs) from 1990 to 2019 were obtained from GBD 2019. Using this data set, we conducted an age-period-cohort (APC) analysis to examine patterns and trends in mortality, prevalence, and disability-adjusted life years (DALYs) associated with CBDs, while exploring correlations with age, time periods, and generational birth cohorts. Furthermore, to quantify the temporal trends, we calculated the estimated annual percentage changes (EAPCs) for these parameters. Results: The global prevalence of CBDs decreased from 1404.22 to 1301.66 per 100 000 with an EAPC of -0.18% from 1990 to 2019. CBD mortality decreased by 42.52% between 1990 and 2019, with the global age-standardised death rate declining from 49.72 to 25.58 per 100 000. The age-standardised DALY rate decreased from 4529.16 to 2393.61 per 100 000. Prevalence declined most notably among older children. The risk of CBDs reached its lowest during adolescence (10-14 years) across all regions. The most recent period (2015-2019) showed a reduced risk of prevalence compared to 2000-2004. Earlier birth cohorts displayed declining tendencies followed by slight increases in risk. Conclusions: This study demonstrates encouraging global reductions in the burden of CBDs among children over the past three decades. Prevalence, mortality, and DALYs attributable to CBDs have exhibited downward trajectories, although regional disparities remain. APC analysis provides valuable insights to inform prevention and management strategies for pediatric CBDs.
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