Evidence map›Paper›PMID 38247506›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via Its

Sotiris Kyriakou, Nikoletta Demosthenous, Tom Amery, Kyle J Stewart, Paul G Winyard, Rodrigo Franco, Aglaia Pappa, Mihalis I Panayiotidis

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Watercress (Life (Basel, Switzerland) · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Sotiris KyriakouDepartment of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.ORCID 0000-0002-6195-6570
Nikoletta DemosthenousDepartment of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.
Tom AmeryThe Watercress Company, Dorchester DT2 8QY, UK.
Kyle J StewartWatercress Research Limited, Unit 24, De Havilland Road, Exeter EX5 2GE, UK.
Paul G WinyardWatercress Research Limited, Unit 24, De Havilland Road, Exeter EX5 2GE, UK.ORCID 0000-0002-9613-1202
Rodrigo FrancoRedox Biology Centre, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.ORCID 0000-0003-3241-8615
Aglaia PappaDepartment of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0913-4315
Mihalis I PanayiotidisDepartment of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.ORCID 0000-0002-1450-3552
Cyprus Institute of Neurology and Genetics · CYDemocritus University of Thrace · GRUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The aim of the current study was to assess the role of a naturally derived PEITC-enriched extract in the induction of oxidative stress and to evaluate its anti-melanoma potency through the regulation of its metabolism with the concurrent production of the

Indexed as

antioxidant enzymesisothiocyanatesmalignant melanomamercapturic acid pathwayoxidative stressphenethyl isothiocyanatepolyphenolswatercress

Identifiers

PMID38247506
PMCPMC10812449
OpenAlexW4390673360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.