ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2024
The Relationship between Depression Severity and Prefrontal Hemodynamic Changes in Adolescents with Major Depression Disorder: A Functional Near-infrared Spectroscopy Study.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- fNIRS-Based characterization of adolescent depression using dynamic functional connectivity biomarkers in a verbal fluency task.BMC psychiatry · 2026Article
- Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non-psychotic adolescent depression during verbal fluency.Frontiers in psychiatry · 2026Article
- Cortical high-threshold and low-activation characteristics in adolescent depression: a cross-age differential analysis.Frontiers in psychiatry · 2026Article
- An Exploratory Functional Near-infrared Spectroscopy Study of Prefrontal Cortex Connectivity during Body Scan Meditation.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- [Prefrontal dysfunction and mismatch negativity in adolescent depression: A multimodal fNIRS-ERP study].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Changes in heart rate variability and hemodynamics of adolescents within the frontal cortex in response to face emotional stimulation.PloS one · 2025Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: : Numerous studies have identified hemodynamic changes in adults with major depressive disorder (MDD) by using functional near-infrared spectroscopy (fNIRS). However, studies on adolescents with MDD are limited. As adolescence is a stage of rapid brain development, differences may occur depending on age. This study used fNIRS as an objective tool to investigate hemodynamic changes in the frontal lobe according to depression severity and age in adolescents with MDD. Methods: : Thirty adolescents (12 aged 12-15 years and 18 aged 16-18 years) were retrospectively investigated. The Children's Depression Inventory was used as a psychiatric evaluation scale, fNIRS was used as an objective brain function evaluation tool, and the Verbal Fluency Test was performed. Results: : During the Verbal Fluency Test, in the younger MDD group, oxygenated-hemoglobin concentration increased in the right dorsolateral prefrontal cortex region as the severity of depression increased. In the older MDD group, the oxygenated-hemoglobin concentration decreased in the right dorsolateral prefrontal cortex region as the severity of depression increased. Conclusion: : These results suggest that fNIRS may be an objective tool for identifying age differences among adolescents with MDD. To generalize the results and verify fNIRS as a potential biomarker tool, follow-up studies with a larger sample group should be conducted.
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