Evidence map›Paper›PMID 38247366›Full record

ArticleNeurourology and urodynamics2024

Ecological momentary assessment of pelvic pain and urinary urgency variability in urologic chronic pelvic pain syndrome and their association with illness impact and quality of life: Findings from the multidisciplinary approach to the study of chronic pelvic pain symptom patterns study.

Bradley A Erickson, James W Griffith, Guo Wensheng, You Mengying, Ted Herman, Catherine S Bradley, J Quentin Clemens, John T Farrar, Priyanka Gupta, Karl J Kreder and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurourology and urodynamics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 1 country.

Bradley A EricksonDepartment of Urology, University of Iowa, Iowa City, Iowa, USA.ORCID http://orcid.org/0000-0001-5237-3464
James W GriffithDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Guo WenshengDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
You MengyingDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ted HermanDepartment of Computer Sciences, University of Lowa College of Liberal Arts and Sciences, Iowa City, Iowa, USA.
Catherine S BradleyDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA.
J Quentin ClemensDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
John T FarrarDepartment of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Priyanka GuptaDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Karl J KrederDepartment of Urology, University of Iowa, Iowa City, Iowa, USA.
H Henry LaiDivision of Urologic Surgery, Department of Surgery, and Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Bruce D NaliboffG. Oppenheimer Center for Neurobiology of Stress and Resilience, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at the University of California, Los Angeles, California, USA.
Diane K NewmanPenn Center for Continence and Pelvic Health, Division of Urology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Larissa V RodriguezDepartment of Urology, Cornell University, New York, New York, USA.
Theresa SpitznagleProgram in Physical Therapy, Washington University School of Medicine, St Louis, Missouri, USA.
Siobhan SutcliffeDivision of Public Health Sciences, Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Suzette E SutherlandDepartment of Urology, University of Washington, Seattle, Washington, USA.
Bayley J TapleDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-5812-5848
J Richard LandisDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0001-8099-0988
University of Pennsylvania · USUniversity of Iowa · USNorthwestern University · USUniversity of Michigan · USWashington University in St. Louis · USAlvin J. Siteman Cancer Center · USCornell University · USUniversity of California, Los Angeles · USUniversity of Washington · US

Funding

MAPP Research NetworkU01DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2008 to 2018
$17.2M
Role of CNS in Modulation of Pelvic Pain SyndromeU01DK082342 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2008 to 2021
$10.5M
Urology Chronic Pelvic Pain Longitudinal Symptom Patterns StudyU01DK082344 · NIDDK · UNIVERSITY OF IOWA · PI KREDER, KARL J · 2008 to 2021
$9.8M
University of Michigan MAPP Research Network Discovery SiteU01DK082345 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLAUW, DANIEL J, CLEMENS, J. QUENTIN · 2008 to 2021
$9.7M
Neurobiological endophenotypes & gene-environment interactions in IC/PBS & in aU01DK082370 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUTCH, JASON J., MAYER, EMERAN A · 2008 to 2021
$9.2M
WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
Washington University MAPP Network Discovery SiteU01DK082315 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2008 to 2021
$9.0M
MAPP Research Network Tissue Analysis and Technology CoreU01DK082333 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LUCIA, M. SCOTT · 2008 to 2018
$6.1M
Limited Competition for Continuation of the MAPP-RN DCCU24DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2019 to 2021
$4.9M
Semi-Parametric Subgroup Analysis for Longitudinal Data with Applications to Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) StudyR01DK117208 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GUO, WENSHENG · 2019 to 2022
$1.5M
MAPP Research Network Tissue Analysis and Technology CoreU24DK082333 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LUCIA, M. SCOTT · 2019 to 2021
$390k
NIDDK NIH HHS R01 DK117208NIDDK NIH HHS U01 DK082315NIDDK NIH HHS U01 DK082316NIDDK NIH HHS U01 DK082325NIDDK NIH HHS U01 DK082333NIDDK NIH HHS U01 DK082342NIDDK NIH HHS U01 DK082344NIDDK NIH HHS U01 DK082345NIDDK NIH HHS U01 DK082370NIDDK NIH HHS U24 DK082316NIDDK NIH HHS U24 DK082333
6 · The paper itself

Abstract

purposeThis study tested the hypothesis that ecological momentary assessment (EMA) of pelvic pain (PP) and urinary urgency (UU) would reveal unique Urologic Chronic Pelvic Pain Syndrome (UCPPS) phenotypes that would be associated with disease specific quality of life (QOL) and illness impact metrics (IIM). MATERIALS AND

methodsA previously validated smart phone app (M-app) was provided to willing Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) participants. M-app notifications were sent 4-times daily for 14 days inquiring about PP and UU severity. A clustering algorithm that accounted for variance placed participants into PP and UU variability? clusters. Associations between clusters and QOL and IIM were then determined.

resultsA total of 204 participants enrolled in the M-app study (64% female). M-app compliance was high (median 63% of surveys). Cluster analysis revealed k = 3 (high, low, none) PP clusters and k = 2 (high, low) UU clusters. When adjusting for baseline pain severity, high PP variability, but not UU variability, was strongly associated with QOL and IIM; specifically worse mood, worse sleep and higher anxiety. UU and PP clusters were associated with each other (p < 0.0001), but a large percentage (33%) of patients with high PP variability had low UU variability.

conclusionsPP variability is an independent predictor of worse QOL and more severe IIM in UCPPS participants after controlling for baseline pain severity and UU. These findings suggest alternative pain indices, such as pain variability and unpredictability, may be useful adjuncts to traditional measures of worst and average pain when assessing UCPPS treatment responses.

Indexed as

Chronic PainQuality of LifeEcological Momentary AssessmentFemaleHumansMalePain MeasurementPelvic Painecological momentary assessmentillness impactphone applicationquality of lifeurologic chronic pelvic pain syndromevariability

Identifiers

PMID38247366
PMCPMC11031348
OpenAlexW4391107498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.