Evidence map›Paper›PMID 38247191›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2024

Design patterns of biological cells.

Steven S Andrews, H Steven Wiley, Herbert M Sauro

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026
    Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Steven S AndrewsDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-4576-8107
H Steven WileyEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA.ORCID 0000-0003-0232-6867
Herbert M SauroDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3659-6817

Funding

TR&D3: Standards and Tools for Simulator Composition and Credibility portalP41EB023912 · NIBIB · UNIVERSITY OF WASHINGTON · PI Ion I. Moraru, HERBERT M. SAURO · 2018 to 2026
$11.4M
Reverse Sensitivity Analysis for Identifying Predictive Proteomics Signatures of CancerU01CA227544 · NCI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI QIAN, WEI-JUN, SAURO, HERBERT M. · 2019 to 2023
$3.1M
NCI NIH HHS U01 CA227544NIBIB NIH HHS P41 EB023912
6 · The paper itself

Abstract

Design patterns are generalized solutions to frequently recurring problems. They were initially developed by architects and computer scientists to create a higher level of abstraction for their designs. Here, we extend these concepts to cell biology to lend a new perspective on the evolved designs of cells' underlying reaction networks. We present a catalog of 21 design patterns divided into three categories: creational patterns describe processes that build the cell, structural patterns describe the layouts of reaction networks, and behavioral patterns describe reaction network function. Applying this pattern language to the E. coli central metabolic reaction network, the yeast pheromone response signaling network, and other examples lends new insights into these systems.

Indexed as

Escherichia coliSignal TransductionMetabolic Networks and PathwaysModels, Biologicalcell biology modelingcell signalingmetabolismsystems biology

Identifiers

PMID38247191
PMCPMC10922931

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.