Evidence map›Paper›PMID 38246950›Full record

ArticleMolecular diversity2024

Anticancer activity features of imidazole-based ionic liquids and lysosomotropic detergents: in silico and in vitro studies.

Anastasiia Gryniukova, Petro Borysko, Iryna Myziuk, Diana Alieksieieva, Diana Hodyna, Ivan Semenyuta, Vasyl Kovalishyn, Larysa Metelytsia, Sergiy Rogalsky, Sergey Tcherniuk

Abstract read
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In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Anastasiia GryniukovaDepartment of Medical and Biological Researches, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Academician Kukhar Str, Kyiv, 02094, Ukraine.ORCID https://orcid.org/0000-0002-6750-0478
Petro BoryskoBienta/Enamine Ltd, 78 Winston Churchill Str, Kyiv, 02094, Ukraine.ORCID http://orcid.org/0000-0002-5840-5233
Iryna MyziukBienta/Enamine Ltd, 78 Winston Churchill Str, Kyiv, 02094, Ukraine.
Diana AlieksieievaBienta/Enamine Ltd, 78 Winston Churchill Str, Kyiv, 02094, Ukraine.ORCID https://orcid.org/0000-0001-7807-1181
Diana HodynaDepartment of Medical and Biological Researches, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Academician Kukhar Str, Kyiv, 02094, Ukraine.ORCID http://orcid.org/0000-0001-6161-9833
Ivan SemenyutaDepartment of Medical and Biological Researches, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Academician Kukhar Str, Kyiv, 02094, Ukraine.ORCID http://orcid.org/0000-0001-8464-3692
Vasyl KovalishynDepartment of Medical and Biological Researches, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Academician Kukhar Str, Kyiv, 02094, Ukraine.ORCID http://orcid.org/0000-0002-9352-7332
Larysa MetelytsiaDepartment of Medical and Biological Researches, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 1 Academician Kukhar Str, Kyiv, 02094, Ukraine.ORCID http://orcid.org/0000-0002-9876-6076
Sergiy RogalskyLaboratory of Modification of Polymers, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, 50 Kharkivske shose, Kyiv, 02160, Ukraine. sergey.rogalsky@gmail.com.ORCID http://orcid.org/0000-0002-5200-5247
Sergey TcherniukIdeSip, 4 Rue Pierre Fontaine, 91058, Évry-Courcouronnes, France. tchernuk@yahoo.com.ORCID http://orcid.org/0000-0003-4052-651X
Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar · UAEnamine (Ukraine) · UAYahoo (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-chain imidazole-based ionic liquids (compounds 2, 4, 9) and lysosomotropic detergents (compounds 7, 3, 8) with potent anticancer activity were synthesized. Their inhibitory activities against neuroblastoma and leukaemia cell lines were predicted by the new in silico QSAR models. The cytotoxic activities of the synthesized imidazole derivatives were investigated on the SK-N-DZ (human neuroblastoma) and K-562 (human chronic myeloid leukaemia) cell lines. Compounds 2 and 7 showed the highest in vitro cytotoxic effect on both cancer cell lines. The docking procedure of compounds 2 and 7 into the NAD

Indexed as

Antineoplastic AgentsDetergentsImidazolesIonic LiquidsMolecular Docking SimulationCell Line, TumorComputer SimulationHumansQuantitative Structure-Activity RelationshipSirtuin 1Antineoplastic AgentsDetergentsimidazoleImidazolesIonic LiquidsSirtuin 1Anticancer activityIonic liquidsLysosomotropic detergentsMolecular docking

Identifiers

PMID38246950
OpenAlexW4391076749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.