Observational studyHepatology international2024
An algorithm for simplified hepatitis C virus treatment with non-specialist care based on nation-wide data from Taiwan.
Open access · hybridAbstract readObservational Study
In one paragraph
Observational study in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- 2025 KASL clinical practice guidelines for management of hepatitis C.Clinical and molecular hepatology · 2026Article
- Simplified and Integrated Hepatitis C Virus Testing and Treatment Algorithm for Unhoused People Who Inject Drugs.Open forum infectious diseases · 2025Article
- Real-world efficacy and safety of universal 8-week glecaprevir/pibrentasvir in patients with chronic hepatitis C with early chronic kidney disease or pre-end-stage renal disease: Insights from a nationwide hepatisis C virus registry in Taiwan.The Kaohsiung journal of medical sciences · 2025Article
- Dynamic change of metabolic dysfunction-associated steatotic liver disease in chronic hepatitis C patients after viral eradication: A nationwide registry study in Taiwan.Clinical and molecular hepatology · 2024Article
- Metformin and statins reduce hepatocellular carcinoma risk in chronic hepatitis C patients with failed antiviral therapy.Clinical and molecular hepatology · 2024Article
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Authors and funding
45 authors at 20 institutions in 1 country.
Ming-Lung YuSchool of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-Sen University, No. 70, Lianhai Rd, Gushan District, Kaohsiung City, Taiwan, 804.
Chi-Ming TaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, No. 1, Section 1, Xuecheng Rd, Dashu District, Kaohsiung City, Taiwan, 840.
Lein-Ray MoDivision of Gastroenterology, Tainan Municipal Hospital (Managed By Show Chwan Medical Care Corporation), No. 670, Chongde Rd, East District, Tainan City, Taiwan, 701.
Hsing-Tao KuoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, No. 901, Zhonghua Rd, Yongkang District, Tainan City, Taiwan, 710.
Chung-Feng HuangSchool of Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-Sen University, No. 70, Lianhai Rd, Gushan District, Kaohsiung City, Taiwan, 804.
Kuo-Chih TsengDepartment of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Minsheng Rd, Dalin Township, Chiayi County, Taiwan, 622.
Ching-Chu LoDivision of Gastroenterology, Department of Internal Medicine, St. Martin De Porres Hospital, No. 60, Minquan Rd, East District, Chiayi City, Taiwan, 600.
Ming-Jong BairDivision of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, No. 1, Lane 303, Zhangsha St, Taitung City, Taitung County, Taiwan, 950.
Szu-Jen WangDivision of Gastroenterology, Department of Internal Medicine, Yuan's General Hospital, No. 162, Chenggong 1st Rd, Lingya District, Kaohsiung City, Taiwan, 802.
Jee-Fu HuangHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shihcyuan 1st Rd, Sanmin District, Kaohsiung City, Taiwan, 807.
Ming-Lun YehHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shihcyuan 1st Rd, Sanmin District, Kaohsiung City, Taiwan, 807.
Chun-Ting ChenDivision of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Rd, Neihu District, Taipei City, Taiwan, 114.
Ming-Chang TsaiSchool of Medicine, Chung Shan Medical University, Department of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Section 1, Jianguo N Rd, South District, Taichung City, Taiwan, 402.
Chien-Wei HuangDivision of Gastroenterology, Kaohsiung Armed Forces General Hospital, No. 2, Zhongzheng 1st Rd, Lingya District, Kaohsiung City, Taiwan, 802.
Pei-Lun LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, No. 901, Zhonghua Rd, Yongkang District, Tainan City, Taiwan, 710.
Tzeng-Hue YangLotung Poh-Ai Hospital, No. 83, Nanchang St, Luodong Township, Yilan County, Taiwan, 265.
Yi-Hsiang HuangDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Rd, Beitou District, Taipei City, Taiwan, 112.
Lee-Won ChongDivision of Hepatology and Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Shilin District, Taipei City, Taiwan, 111.
Chien-Lin ChenDepartment of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, No. 701, Section 3, Zhongyang Rd, Hualien City, Hualien County, Taiwan, 970.
Chi-Chieh YangDepartment of Gastroenterology, Division of Internal Medicine, Show Chwan Memorial Hospital, No. 542, Section 1, Zhongshan Rd, Changhua City, Changhua County, Taiwan, 500.
Chao-Hung HungDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, No. 123, Dapi Rd, Niaosong District, Kaohsiung City, Taiwan, 833.
Sheng-Shun YangDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 1650, Section 4, Taiwan Boulevard, Xitun District, Taichung City, Taiwan, 407.
Pin-Nan ChengDivision of Gastroenterology and Hepatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No. 1, Dasyue Rd, East District, Tainan City, Taiwan, 701.
Tsai-Yuan HsiehDivision of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Rd, Neihu District, Taipei City, Taiwan, 114.
Jui-Ting HuLiver Center, Cathay General Hospital, No. 280, Section 4, Ren'ai Rd, Da'an District, Taipei City, Taiwan, 106.
Wen-Chih WuWen-Chih Wu Clinic, Fengshan, Kaohsiung, Taiwan, 830.
Chien-Yu ChengDivision of Infectious Diseases, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, No. 1492, Zhongshan Rd, Taoyuan District, Taoyuan City, Taiwan, 330.
Guei-Ying ChenPenghu Hospital, Ministry of Health and Welfare, No. 10, Zhongzheng Rd, Magong City, Penghu County, Taiwan, 880.
Guo-Xiong ZhouZhou Guoxiong Clinic, Penghu, Taiwan, 880.
Wei-Lun TsaiKaohsiung Veterans General Hospital, No. 386, Dazhong 1st Rd, Zuoying District, Kaohsiung City, Taiwan, 813.
Chien-Neng KaoNational Taiwan University Hospital Hsin-Chu Branch, No. 25, Lane 442, Section 1, Jingguo Rd, North District, Hsinchu City, Taiwan, 300.
Chih-Lang LinLiver Research Unit, Department of Hepato-Gastroenterology and Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, College of Medicine, Chang Gung University, No. 222, Maijin Rd, Anle District, Keelung City, Taiwan, 204.
Chia-Chi WangTaipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, No. 289, Jianguo Rd, Xindian District, New Taipei City, Taiwan, 231.
Ta-Ya LinCishan Hospital, Ministry of Health and Welfare, No. 60, Zhongxue Rd, Qishan District, Kaohsiung City, Taiwan, 842.
Chih-Lin LinDepartment of Gastroenterology, Renai Branch, Taipei City Hospital, No. 10, Section 4, Ren'ai Rd, Da'an District, Taipei City, Taiwan, 106.
Wei-Wen SuDepartment of Gastroenterology and Hepatology, Changhua Christian Hospital, No. 176, Zhonghua Rd, Changhua City, Changhua County, Taiwan, 500.
Tzong-Hsi LeeDivision of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, No. 21, Section 2, Nanya S Rd, Banqiao District, New Taipei City, Taiwan, 220.
Te-Sheng ChangDivision of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan and College of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd, Guishan District, Taoyuan City, Taiwan, 333.
Chun-Jen LiuHepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, No. 1, Section 4, Roosevelt Rd, Da'an District, Taipei City, Taiwan, 106.
Chia-Yen DaiHepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shihcyuan 1st Rd, Sanmin District, Kaohsiung City, Taiwan, 807.
Chi-Yi ChenDivision of Gastroenterology and Hepatology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, No. 539, Zhongxiao Rd, East District, Chiayi City, Taiwan, 600.
Jia-Horng KaoHepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, No. 1, Section 4, Roosevelt Rd, Da'an District, Taipei City, Taiwan, 106.
Han-Chieh LinDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Rd, Beitou District, Taipei City, Taiwan, 112.
Wan-Long Chuang *Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Shihcyuan 1st Rd, Sanmin District, Kaohsiung City, Taiwan, 807. waloch@kmu.edu.tw.ORCID http://orcid.org/0000-0002-2376-421X
Cheng-Yuan Peng *Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Rd, North District, Taichung City, Taiwan, 404. cypeng@mail.cmuh.org.tw.
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWTri-Service General Hospital · TWChang Gung University · TWNational Taiwan University Hospital · TWNational Yang Ming Chiao Tung University · TWTzu Chi University · TWCathay General Hospital · TWChang Bing Show Chwan Memorial Hospital · TWChanghua Christian Hospital · TWChi Mei Medical Center · TWChina Medical University · TWChung Shan Medical University Hospital · TWE-Da Hospital · TWFar Eastern Memorial Hospital · TWFu Jen Catholic University · TWKaohsiung Chang Gung Memorial Hospital · TWKaohsiung Veterans General Hospital · TWLuodong Poh-Ai Hospital · TWMackay Memorial Hospital · TW
Funding
Kaohsiung Medical University 105KMUOR08Kaohsiung Medical University KMU-DK109002Kaohsiung Medical University KMU-K1110002Kaohsiung Medical University KMU-TC108B06Kaohsiung Medical University KMU-TC108B07Kaohsiung Medical University KMU-TC109B05Kaohsiung Medical University MOST 108-2314-B-037-066-MY3Kaohsiung Medical University MOST 109-2314-B-037-044Kaohsiung Medical University Hospital KMHK-DK(C)111004Kaohsiung Medical University Hospital KMHK-DK(C)111006Kaohsiung Medical University Hospital KMUH109-9R05Kaohsiung Medical University Hospital KMUH109-9R06Kaohsiung Medical University Hospital KMUH-IIT-109-2-05Kaohsiung Medical University Hospital MOHW109-TDU-B-212-114006Ministry of Education Kaohsiung" from The Featured Areas Research Center Program within the framework of the Higher Education Sprout ProjectMinistry of Education National Sun Yat-sen UniversityMinistry of Education The "Center of Excellence for Metabolic Associated Fatty Liver Disease
Abstract
backgroundBoth European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Diseases and the Infectious Diseases Society of America (AASLD-IDSA) guidelines recommend simplified hepatitis C virus (HCV) treatment with pan-genotypic sofosbuvir/velpatasvir or glecaprevir/pibrentasvir for eligible patients. This observational study used real-world data to assess these regimens' safety in eligible patients and develop an algorithm to identify patients suitable for simplified treatment by non-specialists.
methods7,677 HCV-infected patients from Taiwan Hepatitis C Registry (TACR) who received at least one dose of sofosbuvir/velpatasvir or glecaprevir/pibrentasvir, and fulfilled the EASL/AASLD-IDSA criteria for simplified treatment were analyzed. Multivariate analysis was conducted on patient characteristics and safety data.
resultsOverall, 92.8% (7,128/7,677) of patients achieved sustained virological response and only 1.9% (146/7,677) experienced Grades 2-4 laboratory abnormalities in key liver function parameters (alanine aminotransferase, aspartate aminotransferase, and total bilirubin), with only 18 patients (0.23%) experiencing Grades 3-4 abnormalities. Age > 70 years old, presence of hepatocellular carcinoma, total bilirubin > 1.2 mg/dL, estimated glomerular filtration rate < 60 mL/min/1.73 m
conclusionsReal-world data from Taiwan confirmed that simplified HCV treatment for eligible patients with pan-genotypic regimens is effective and well tolerated. The TACR algorithm, developed based on this study's results, can further identify patients who can be safely managed by non-specialist care.
Indexed as
Aminoisobutyric AcidsBenzimidazolesBenzopyransCarbamatesCyclopropanesHepatitis CHepatitis C, ChronicHeterocyclic Compounds, 4 or More RingsLactams, MacrocyclicLiver NeoplasmsSulfonamidesAgedAntiviral AgentsBilirubinGenotypeHepacivirusAminoisobutyric AcidsAntiviral AgentsBenzimidazolesBenzopyransBilirubinCarbamatesCyclopropanesglecaprevirHeterocyclic Compounds, 4 or More RingsLactams, MacrocyclicLeucineProlineQuinoxalinesSofosbuvirSulfonamidesvelpatasvirAmerican Association for the Study of Liver Diseases and the Infectious Diseases Society of AmericaDirect-acting antiviralsEuropean Association for the Study of the Liverglecaprevir/pibrentasvirLaboratory abnormalitiesLiver functionSafetySimplified treatmentsofosbuvir/velpatasvirTaiwan hepatitis C registry
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