ArticlePlant cell reports2024
The maize WRKY transcription factor ZmWRKY64 confers cadmium tolerance in Arabidopsis and maize (Zea mays L.).
Article in Plant cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Transcription Factor TCP9 EnhancesPlants (Basel, Switzerland) · 2026Article
- Genetic basis of cadmium accumulation and tolerance in maize seedlings uncovered through integrated linkage mapping and transcriptome analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- A NAC transcription factor MdNAC1 enhances cadmium tolerance in apple.Plant cell reports · 2026Article
- Multi-omics analysis reveals molecular mechanisms of maize responses to hexavalent chromium toxicity.BMC plant biology · 2026Article
- Genome-wide identification and gene expression analysis of AhNHXs in peanut.BMC plant biology · 2026Article
- Genome-wide identification and functional analysis of the WRKY transcription factor family in Reynoutria japonica reveals its role in balancing growth and abiotic stress tolerance.BMC plant biology · 2026Article
- The Maize WRKY Transcription Factor ZmWRKY4 Confers Lead Tolerance by RegulatingPlants (Basel, Switzerland) · 2026Article
- ZmHSFA2d positively regulates maize seedling heat and drought tolerance by modulating photosystem protein synthesis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Genome-Wide Analysis ofGenes · 2025Article
- Comprehensive identification and expression analysis of the CPP gene family in maize (Zea mays L.).BMC plant biology · 2025Article
- Interplay between auxin and abiotic stresses in maize.Journal of experimental botany · 2025Review
- Genome-wide characterization and expression analysis of WRKY family genes in the biosynthesis of triptolide in Tripterygium wilfordii.BMC genomics · 2025Article
- RsWRKY75 promotes ROS scavenging and cadmium efflux via activating the transcription of RsAPX1 and RsPDR8 in radish (Raphanus sativus L.).Plant cell reports · 2025Article
- Genome-wide identiffcation of the WRKY gene family in poplar and the positive role of PsnWRKY95 in response to cadmium stress.PloS one · 2025Article
- Screening for cold tolerance resources in maize seedlings and analysis of leaf cell responses.Frontiers in plant science · 2025Article
- Transcriptome analysis unveils the functional effects of ectomycorrhizal fungal colonization on cadmium tolerance of willow saplings.Frontiers in microbiology · 2025Article
- Identification, characterization, and expression analysis of WRKY transcription factors inFrontiers in plant science · 2025Article
- Article
- WRKY Transcription Factors in Response to Metal Stress in Plants: A Review.International journal of molecular sciences · 2024Review
- Metal transport proteins and transcription factor networks in plant responses to cadmium stress.Plant cell reports · 2024Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
key messageZmWRKY64 positively regulates Arabidopsis and maize Cd stress through modulating Cd uptake, translocation, and ROS scavenging genes expression. Cadmium (Cd) is a highly toxic heavy metal with severe impacts on crops growth and development. The WRKY transcription factor is a significant regulator influencing plant stress response. Nevertheless, the function of the WRKY protein in maize Cd stress response remains unclear. Here, we identified a maize WRKY gene, ZmWRKY64, the expression of which was enhanced in maize roots and leaves under Cd stress. ZmWRKY64 was localized in the nucleus and displayed transcriptional activity in yeast. Heterologous expression of ZmWRKY64 in Arabidopsis diminished Cd accumulation in plants by negatively regulating the expression of AtIRT1, AtZIP1, AtHMA2, AtNRAMP3, and AtNRAMP4, which are involved in Cd uptake and transport, resulting in Cd stress tolerance. Knockdown of ZmWRKY64 in maize led to excessive Cd accumulation in leaf cells and in the cytosol of the root cells, resulting in a Cd hypersensitive phenotype. Further analysis confirmed that ZmWRKY64 positively regulated ZmABCC4, ZmHMA3, ZmNRAMP5, ZmPIN2, ZmABCG51, ZmABCB13/32, and ZmABCB10, which may influence Cd translocation and auxin transport, thus mitigating Cd toxicity in maize. Moreover, ZmWRKY64 could directly enhance the transcription of ZmSRG7, a reported key gene regulating reactive oxygen species homeostasis under abiotic stress. Our results indicate that ZmWRKY64 is important in maize Cd stress response. This work provides new insights into the WRKY transcription factor regulatory mechanism under a Cd-polluted environment and may lead to the genetic improvement of Cd tolerance in maize.
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