Evidence map›Paper›PMID 38245880›Full record

ArticleEpigenetics2024

Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection.

Renan da Silva Santos, Daniel Pascoalino Pinheiro, Carlos Gustavo Hirth, Maria Júlia Barbosa Bezerra, Isabelle Joyce de Lima Silva-Fernandes, Francisca Andréa da Silva Oliveira, Maisa Viana de Holanda Barros, Ester Silveira Ramos, Arlindo A Moura, Odorico de Moraes Manoel Filho and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Renan da Silva SantosDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID 0000-0003-2502-508X
Daniel Pascoalino PinheiroOswaldo Cruz Foundation, FIOCRUZ-Ceará, Sector of Biotechnology, Eusebio, Ceará, Brazil.ORCID 0000-0002-5499-5547
Carlos Gustavo HirthLaboratory of Pathology, Cancer Institute of Ceará, Fortaleza, Ceará, Brazil.
Maria Júlia Barbosa BezerraLaboratory of Molecular Biology and Genetics, Cancer Institute of Ceará, Fortaleza, Ceará, Brazil.
Isabelle Joyce de Lima Silva-FernandesLaboratory of Molecular Biology and Genetics, Cancer Institute of Ceará, Fortaleza, Ceará, Brazil.
Francisca Andréa da Silva OliveiraGenomics and Bioinformatics Center, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Maisa Viana de Holanda BarrosPostgraduate Program in Translational Medicine, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Ester Silveira RamosDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Arlindo A MouraDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Odorico de Moraes Manoel FilhoDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Claudia PessoaDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Cristiana Libardi Miranda FurtadoPostgraduate Program in Translational Medicine, Drug Research and Development Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.ORCID 0000-0002-8711-8225
Universidade Federal do Ceará · BRHospital Haroldo Juaçaba · BRFundação Oswaldo Cruz · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to lifestyle behaviour and human papillomavirus (HPV) infection. Environmentally induced loss of imprinting (LOI) at the H19 differentially methylated region (H19DMR) is associated with many cancers in the early events of tumorigenesis and may be involved in the pathogenesis of penile SCC. We sought to evaluate the DNA methylation pattern at H19DMR and its association with HPV infection in men with penile SCC by bisulfite sequencing (bis-seq). We observed an average methylation of 32.2% ± 11.6% at the H19DMR of penile SCC and did not observe an association between the p16

Indexed as

Carcinoma, Squamous CellPapillomavirus InfectionsRNA, Long NoncodingCarcinogenesisCyclin-Dependent Kinase Inhibitor p16DNA MethylationHumansMaleCyclin-Dependent Kinase Inhibitor p16RNA, Long Noncodinggenomic imprintingH19DMRhuman papillomavirushypomethylationPenile squamous cell carcinomasingle nucleotide polymorphism

Identifiers

PMID38245880
PMCPMC10802203
OpenAlexW4391062216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.