Evidence map›Paper›PMID 38245545›Full record

ArticleNPJ vaccines2024

Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2.

Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen and 14 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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  18. Intranasal Delivery ofVaccines · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 3 countries.

Klara LenartDepartment of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4984-2618
Rodrigo Arcoverde Cerveira *Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1145-2534
Fredrika Hellgren *Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Sebastian OlsDepartment of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9784-7176
Daniel J ShewardDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0227-5636
Changil KimDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4977-4384
Alberto CagigiDepartment of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Matthew GagneVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5526-6162
Brandon DavisRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Daritza GermosenRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Vicky RoyRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5064-1098
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Hélène LetscherUniversité Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.
Jérôme Van WassenhoveUniversité Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.ORCID http://orcid.org/0000-0001-7298-465X
Wesley GrosUniversité Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.
Anne-Sophie GallouëtUniversité Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.
Roger Le GrandUniversité Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.ORCID http://orcid.org/0000-0002-4928-4484
Harry KleanthousBill & Melinda Gates Foundation, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7115-235X
Mimi Guebre-XabierNovavax Inc, Gaithersburg, MD, USA.
Ben MurrellDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0393-4445
Nita PatelNovavax Inc, Gaithersburg, MD, USA.
Gregory GlennNovavax Inc, Gaithersburg, MD, USA.
Gale SmithNovavax Inc, Gaithersburg, MD, USA.ORCID http://orcid.org/0000-0002-6482-6026
Karin LoréDepartment of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden. karin.lore@ki.se.ORCID http://orcid.org/0000-0001-7679-9494
Karolinska University Hospital · SEInserm · FRNovavax (United States) · USRagon Institute of MGH, MIT and Harvard · USKarolinska Institutet · SEGates Foundation · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immune responses to Novavax's licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-M

Identifiers

PMID38245545
PMCPMC10799869
OpenAlexW4391044403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.