Evidence map›Paper›PMID 38245543›Full record

ArticleNPJ Regenerative medicine2024

MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis.

Maneesh Dave, Atul Dev, Rodrigo A Somoza, Nan Zhao, Satish Viswanath, Pooja Rani Mina, Prathyush Chirra, Verena Carola Obmann, Ganapati H Mahabeleshwar, Paola Menghini and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  4. The theory of the inflammatory ecosystem.Science China. Life sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Maneesh DaveDivision of Gastroenterology and Hepatology, Department of Internal Medicine, UC Davis Medical Center, University of California Davis School of Medicine, Sacramento, CA, USA. mdave@ucdavis.edu.ORCID http://orcid.org/0000-0002-4068-6700
Atul DevDivision of Gastroenterology and Hepatology, Department of Internal Medicine, UC Davis Medical Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Rodrigo A SomozaSkeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH, USA.
Nan ZhaoDivision of Gastroenterology and Liver Disease, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.
Satish ViswanathDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Pooja Rani MinaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, UC Davis Medical Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Prathyush ChirraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Verena Carola ObmannDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Ganapati H MahabeleshwarDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Paola MenghiniDivision of Gastroenterology and Liver Disease, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.
Blythe Durbin-JohnsonDivision of Biostatistics, Department of Public Health Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Jan NoltaInstitute for Regenerative Cures, University of California Davis School of Medicine, Sacramento, CA, USA.
Christopher SotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, UC Davis Medical Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Abdullah OsmeDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Lam T KhuatDepartment of Dermatology, University of California Davis School of Medicine, Sacramento, CA, USA.
William J MurphyDivision of Malignant Hematology/Cell and Marrow Transplantation, Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, USA.
Arnold I CaplanSkeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH, USA.
Fabio CominelliDivision of Gastroenterology and Liver Disease, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.
Case Western Reserve University · USUniversity of California, Davis · USUniversity of California Davis Medical Center · USCalifornia Institute for Regenerative Medicine · USUniversity of Bern · CH

Funding

Ubiquitination Pathways Mediating Chronic Intestinal InflammationP01DK091222 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI PIZARRO, THERESA TORRES · 2011 to 2020
$16.5M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
TR&D-4: Growing Tissue in the Scalable, Modular, Automated, and Closed (SMAC) FoundryP41EB021911 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI HARIHARA BASKARAN · 2016 to 2026
$13.9M
CYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7M
CYTOKINES AND INFLAMMATORY BOWEL DISEASER37DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2009
$3.8M
Role of KLF6 in macrophage lipid homeostasis and atherogenesisR01HL126626 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MAHABALESHWAR, GANAPATI HOLANAGADDE · 2015 to 2019
$2.0M
Role of CITED2 in cardiovascular diseaseR01HL141423 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MAHABALESHWAR, GANAPATI HOLANAGADDE · 2018 to 2021
$1.6M
RadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4M
Novel immunosuppressive mechanism of human bone marrow mesenchymal stem cells in experimental Crohn’s diseaseK08DK110421 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DAVE, MANEESH · 2017 to 2023
$980k
Cytokines and Inflammatory Bowel DiseaseR56DK042191 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COMINELLI, FABIO · 2010 to 2010
$504k
Radiomics-based Risk Prediction for Therapy Selection in Crohn’s Disease via MRIF31DK130587 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI CHIRRA, PRATHYUSH V · 2022 to 2022
$35k
NCI NIH HHS U01 CA248226NHLBI NIH HHS R01 HL126626NHLBI NIH HHS R01 HL141423NIBIB NIH HHS P41 EB021911NIDDK NIH HHS F31 DK130587NIDDK NIH HHS K08 DK110421NIDDK NIH HHS P01 DK091222NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS R37 DK042191NIDDK NIH HHS R56 DK042191
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are novel therapeutics for the treatment of Crohn's disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc (SAMP), a chronic and spontaneous murine model of small intestinal inflammation, to study the therapeutic effects and mechanism of action of human bone marrow-derived MSCs (hMSC). hMSC dose-dependently inhibited naïve T lymphocyte proliferation via prostaglandin E

Identifiers

PMID38245543
PMCPMC10799947
OpenAlexW4391051350

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.