Evidence map›Paper›PMID 38244609›Full record

ArticleRheumatology (Oxford, England)2024

Detection of inflammation by whole-body MRI in young people with juvenile idiopathic arthritis.

Varvara Choida, Timothy J P Bray, Niels van Vucht, Maaz Ali Abbasi, Alan Bainbridge, Thomas Parry, Debajit Sen, Sue Mallett, Coziana Ciurtin, Margaret A Hall-Craggs

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In one paragraph

Article in Rheumatology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Varvara ChoidaCentre for Medical Imaging, University College London, University College London, London, UK.ORCID 0000-0003-2418-9648
Timothy J P BrayCentre for Medical Imaging, University College London, University College London, London, UK.
Niels van VuchtDepartment of Imaging, University College London Hospitals NHS Foundation Trust, London, UK.
Maaz Ali AbbasiDepartment of Imaging, University College London Hospitals NHS Foundation Trust, London, UK.
Alan BainbridgeCentre for Medical Imaging, University College London, University College London, London, UK.
Thomas ParryCentre for Medical Imaging, University College London, University College London, London, UK.
Debajit SenCentre for Adolescent Rheumatology, Division of Medicine, University College London, London, UK.
Sue MallettCentre for Medical Imaging, University College London, University College London, London, UK.
Coziana CiurtinCentre for Adolescent Rheumatology, Division of Medicine, University College London, London, UK.ORCID 0000-0002-8911-4113
Margaret A Hall-CraggsCentre for Medical Imaging, University College London, University College London, London, UK.
University College London Hospitals NHS Foundation Trust · GBUniversity College London · GBUniversity College Hospital · GB

Funding

Action Medical Research and Humanimal TrustBiomedical Research Centre BRC 525 III/CC 101350British Society of Rheumatology 179978Centre for Adolescent Rheumatology Versus Arthritis 21593Centre of ExcellenceDepartment of HealthNational Health ServiceNational Institute for Health ResearchThe Albert Gubay Foundation GN 2697University College London Hospitals
6 · The paper itself

Abstract

objectivesTo assess the frequency of joint inflammation detected by whole-body MRI (WBMRI) in young people (YP) with JIA and controls, and to determine the relationship between WBMRI-detected inflammation and clinical findings.

methodsYP aged 14-24 years, with JIA (patients) or arthralgia without JIA (controls), recruited from one centre, underwent a WBMRI scan after formal clinical assessment. Consensus between at least two of the three independent radiologists was required to define inflammation and damage on WBMRI, according to predefined criteria. YP with JIA were deemed clinically active as per accepted definitions. The proportions of YP with positive WBMRI scans for joint inflammation (one or more inflamed joint) as well as serum biomarkers were compared between active vs inactive JIA patients and controls.

resultsForty-seven YP with JIA (25 active and 22 inactive patients) and 13 controls were included. WBMRI detected joint inflammation in 60% (28/47) of patients with JIA vs 15% (2/13) of controls (difference: 44%, 95% CI 20%, 68%). More active than inactive JIA patients had WBMRI-detected inflammation [76% (19/25) vs 41% (9/22), difference: 35% (95% CI 9%, 62%)], and this was associated with a specific biomarker signature. WBMRI identified inflammation in one or more clinically inactive joint in 23/47 (49%) patients (14/25 active vs 9/22 inactive JIA patients).

conclusionsWBMRI's validity in joint assessment was demonstrated by the higher frequency of inflammation in JIA patients vs controls, and in active vs inactive JIA patients. WBMRI found unsuspected joint inflammation in 49% YP with JIA, which needs further investigation of potential clinical implications.

Indexed as

Arthritis, JuvenileMagnetic Resonance ImagingWhole Body ImagingAdolescentBiomarkersCase-Control StudiesFemaleHumansInflammationMaleYoung AdultBiomarkersdisease activityJIAMMP-3MRIoutcomessynovitisVEGFwhole-body

Identifiers

PMID38244609
PMCPMC11381681
OpenAlexW4391057712

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.